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Peripheral Serotonin Controls Dietary Fat Absorption and Chylomicron Secretion via 5-HT4 Receptor in Males.
Endocrinology
August 2024
Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Postprandial dyslipidemia is commonly present in people with type 2 diabetes and obesity and is characterized by overproduction of apolipoprotein B48-containing chylomicron particles from the intestine. Peripheral serotonin is emerging as a regulator of energy homeostasis with profound implications for obesity; however, its role in dietary fat absorption and chylomicron production is unknown. Chylomicron production was assessed in Syrian golden hamsters by administering an olive oil gavage and IP poloxamer to inhibit lipoprotein clearance.
View Article and Find Full Text PDFQTc Interval Reference Values and Their (Non)-Maturational Factors in Neonates and Infants: A Systematic Review.
Children (Basel)
November 2022
Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
QTc interval measurement is a widely used screening tool to assess the risk of cardiac diseases, arrhythmias, and is a useful biomarker for pharmacovigilance. However, the interpretation of QTc is difficult in neonates due to hemodynamic maturational changes and uncertainties on reference values. To describe trends in QTc values throughout infancy (1 year of life), and to explore the impact of (non)-maturational changes and medicines exposure, a structured systematic review (PROSPERO CRD42022302296) was performed.
View Article and Find Full Text PDFvolatile oil up-regulated IGF-1 to improve diabetic gastroparesis in rats.
Iran J Basic Med Sci
April 2022
Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China.
Objectives: Diabetic gastroparesis (DGP) is one of the main complications of diabetes, and more than half of diabetes cases are accompanied by gastroparesis. This study aims to explore the effect of volatile oil (ACVO) on DGP rats.
Materials And Methods: The rats were injected with STZ combined with a high-sugar and high-fat diet in an irregular manner to establish the DGP model.
Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis.
Cochrane Database Syst Rev
December 2021
Academic Department of Child Health, Royal Stoke University Hospital, Stoke-on-Trent, UK.
Background: Cystic fibrosis (CF) is the most common, life-limiting, genetically inherited disease. It affects multiple organs, particularly the respiratory system. However, gastrointestinal problems such as constipation and distal intestinal obstruction syndrome (DIOS) are also important and well-recognised complications in CF.
View Article and Find Full Text PDFFunctional dyspepsia is one of the most common functional disorders of the gastrointestinal tract, which resulted from impaired motor skills, visceral hypersensitivity, increased mucosal permeability, disorders of the autonomic nervous system, etc. There is no specific therapy for this disease, which often leads to the irrational use of various groups of drugs. Drug therapy is recommended only during periods of symptoms.
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