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Copper-catalyzed nitrogen loss of sulfonylhydrazones: a reductive strategy for the synthesis of sulfones from carbonyl compounds. | LitMetric

Copper-catalyzed nitrogen loss of sulfonylhydrazones: a reductive strategy for the synthesis of sulfones from carbonyl compounds.

Org Lett

Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichaun 610064, PR China.

Published: October 2010

AI Article Synopsis

  • A new method for making sulfones has been developed, using sulfonyl hydrazones, which are derived from carbonyl compounds.
  • The synthesis occurs through a process involving the loss of nitrogen, facilitated by a simple copper salt and a base.
  • This technique successfully produces a range of aryl and alkyl sulfones with moderate to good yield results.

Article Abstract

An efficient method for the synthesis of sulfones via nitrogen loss of sulfonyl hydrazones is described. The reaction was performed in the presence of simple copper salt and base by utilization of sulfonyl hydrazones, which were easily prepared from carbonyl compounds. A wide variety of aryl and alkyl sulfones were obtained in moderate to good yields.

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Source
http://dx.doi.org/10.1021/ol101955xDOI Listing

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