Background: Massive bone loss of the elbow in young patients is a complex injury. A series of five cases of massive loss of the elbow joint reconstructed with single or double vascularized bone transfers is reported.
Methods: Five patients with nonacute massive bone loss of the distal humerus (two cases) or distal humerus and proximal ulna (three cases) were reconstructed with a single (two cases) or double (three cases) microvascular vascularized bone transfer from the iliac crest, the fibula, or the scapula. Collateral ligament reconstruction was performed in a second stage. Follow-up was 1 to 3 years.
Results: All free flaps survived. There was one septic complication not affecting flap survival. The number of surgical procedures was 3.2 (range, two to five). Active range of motion was 86 degrees (range, 70 to 100 degrees), without significant pain and acceptable lateral stability. Treatment time was 7 to 13 months.
Conclusions: Vascularized bone transfer can restore the articular gross anatomy in cases of massive destruction of the elbow. Midterm functional results have been favorable in a short series of young patients.
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http://dx.doi.org/10.1097/PRS.0b013e3181e6b0b9 | DOI Listing |
Clin Transl Med
January 2025
Vascular Research Laboratory, IIS-Fundación Jiménez Díaz, Madrid, Spain.
Background: Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids and leukocytes within the arterial wall. By studying the aortic transcriptome of atherosclerosis-prone apolipoprotein E (ApoE) mice, we aimed to identify novel players in the progression of atherosclerosis.
Methods: RNA-Seq analysis was performed on aortas from ApoE and wild-type mice.
Front Bioeng Biotechnol
January 2025
Qujing Affiliated Hospital of Kunming Medical University, Qujing, China.
Researchers in the field of regenerative medicine have consistently focused on the biomimetic design of engineered bone materials on the basis of the microstructure of natural bone tissue. Additionally, the effects of the micromorphological characteristics of these materials on angiogenesis have garnered increasing attention. , the orientation and diameter of scaffold materials can exert different effects on osteogenesis and vascularisation.
View Article and Find Full Text PDFFront Bioeng Biotechnol
January 2025
Clinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany.
This study investigates the mechanical properties as well as and cyto- and biocompatibility of collagen membranes cross-linked with glutaraldehyde (GA), proanthocyanidins (PC), hexamethylendiisocyanate (HMDI) and 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EC/NHS). A non-crosslinked membrane was used as reference control (RF). The initial cytotoxic analyses revealed that the PC, EC, and HMDI crosslinked membranes were cytocompatible, while the GA crosslinked membrane was cytotoxic and thus selected as positive control in the further study.
View Article and Find Full Text PDFBMC Oral Health
January 2025
Faculty of Dentistry Department of Oral and Maxillofacial Radiology, Ondokuz Mayıs University, Atakum/Samsun, Turkey.
Aim: This study aimed to evaluate the prevalence, location and diameters of Posterior superior alveolar artery (PSAA) and Infraorbital foramen (IOF) to find out whether there is any relationship between PSAA and IOF, and to predict their location relative to each other in surgical procedures by using cone beam computed tomography (CBCT).
Material And Method: Bilateral maxillary sinuses were analysed retrospectively in 170 patients with no missing teeth in the maxillary posterior region. The largest locations of PSAA and IOF in the maxillary sinus were determined and their size, shape, location in relation to the teeth and distances from anatomical points were evaluated.
Neurosurg Rev
January 2025
Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, USA.
The purpose of the current study was to determine the angulation of the dural venous sinuses in soft tissue, to evaluate differences between types of tissue, and to discuss the potential influence of these angulations on intracranial venous hemodynamics and related pathologies. Angulations formed in different segments of the transverse, sigmoid, and superior sagittal sinuses were measured in 13 adult human cadaveric heads (26 sides). After the soft tissues were removed, measurements were also taken from the underlying bone.
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