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Variability of the polymerase gene (NS5B) in hepatitis C virus-infected women. | LitMetric
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Variability of the polymerase gene (NS5B) in hepatitis C virus-infected women.

Jason T Blackard Gang Ma Berkeley N Limketkai Jeffrey A Welge Peter D Dryer Christina M Martin Yoichi Hiasa Lynn E Taylor Kenneth H Mayer Denise J Jamieson Kenneth E Sherman

J Clin Microbiol

Department of Internal Medicine, Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA.

Published: November 2010

There are limited data on diversity within the hepatitis C virus polymerase (NS5B). In concordance with its key functional role during the life cycle, NS5B intrapatient variability was low. Moreover, differences between NS5B nonsynonymous (dN) and synonymous (dS) mutation rates (dN - dS) were positively correlated with CD4 cell count, while nonsynonymous mutations were strongly correlated with reduced replication in vivo.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020841PMC
http://dx.doi.org/10.1128/JCM.01613-10DOI Listing

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