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The possible connection between neutrophil-to-high-density lipoprotein ratio and cerebral perfusion in clinically established corticobasal syndrome: a pilot study.
Front Neurol
October 2024
Department of Neurology, Medical University of Warsaw, Warsaw, Poland.
Introduction: Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are tauopathic atypical parkinsonisms. Given their overlap in terms of clinical manifestation, there is growing interest in the mechanisms leading to these entities.
Materials And Methods: In total, 71 patients were included in the study, 19 of whom were clinically diagnosed with CBS, 37 with PSP, and 15 with Parkinson's disease (PD).
First-in-human infection imaging with Zr-labelled leukocytes and comparison of scan quality with [Tc]Tc-HMPAO-labelled leukocytes.
Front Nucl Med
July 2024
Nuclear Medicine Research Infrastructure (NuMeRI) and Department of Nuclear Medicine, Steve Biko Academic Hospital, University of Pretoria, Pretoria, South Africa.
Article Synopsis
- Nuclear medicine infection imaging typically uses technetium-99m radiolabelled leukocytes with SPECT, but zirconium-89 offers improved sensitivity and image quality through PET technology, allowing delayed imaging for better accuracy in locating infections.
- A study explored the application of zirconium-labelled leukocytes for infection imaging in patients, comparing results from PET and SPECT to assess the quality and distribution of these radiolabelled cells.
- Results showed successful labelling with high efficiency and viability of the zirconium-labelled leukocytes, indicating potential benefits over traditional imaging methods.
The [Tc]Tc-HMPAO-labelled white blood cell SPECT/CT as a novel criterion for infective endocarditis diagnosis.
Int J Cardiol
December 2024
Jagiellonian University Medical College, Department of Cardiac and Vascular Diseases, John Paul II Hospital, Krakow, Poland; John Paul II Hospital, Department of Nuclear Medicine, Krakow, Poland.
Article Synopsis
- In a study of 205 adults suspected of having IE, [Tc]Tc-HMPAO-SPECT/CT scans showed a positive result in 35.1% of cases, and the technique also revealed extracardiac infections in 25% of scans.
- The study concluded that using [Tc]Tc-HMPAO-SPECT/CT enhances the diagnostic performance for IE by improving sensitivity and negative predictive value, which can lead to better patient outcomes and potentially lower rates of misdiagn
C-peptide: an essential ally in microvascular complications of type 2 diabetes mellitus and obesity.
Diabetol Metab Syndr
August 2024
Division of Metabolic Diseases, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei Krt. 98, Debrecen, 4032, Hungary.
Background: In order to investigate microvascular complications in metabolic diseases, we aimed to investigate cerebral and peripheral microcirculation in relation to peripheral neuropathy and laboratory biomarkers in type 2 diabetes mellitus (T2DM) and obesity.
Methods: Based on the degree of neuropathy (NP), study participants (40 T2DM and 30 obese individuals) were classified into no-NP, mild-NP and severe-NP subgroups. After the injection of Technetium-99 m hexamethylpropylene amine oxime, both T2DM and obese participants underwent single-photon emission computed tomography/computed tomography ([99mTc]Tc-HMPAO SPECT/CT) and SPECT-only examinations to assess lower limb and brain perfusion; respectively.
Magnetic Resonance Imaging and 99Tc WBC-SPECT/CT Scanning in Differential Diagnosis between Osteomyelitis and Charcot Neuroarthropathy: A Case Series.
Tomography
August 2024
Department of Radiology, IRCCS INRCA, 60127 Ancona, Italy.
Background: Distinguishing between Charcot Neuroarthropathy (CN), osteomyelitis (OM), and CN complicated with superimposed OM in diabetic patients is crucial for the treatment choice. Given that current diagnostic methods lack specificity, advanced techniques, e.g.
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