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Cell therapies for viral diseases: a new frontier.
Semin Immunopathol
January 2025
Department of Microbiology and Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Despite advances in medicine and antimicrobial research, viral infections continue to pose a major threat to human health. While major strides have been made in generating vaccines and small molecules to combat emerging pathogens, new modalities of treatment are warranted in diseases where there is a lack of treatment options, or where treatment cannot fully eradicate pathogens, as in HIV infection. Cellular therapies, some of which are FDA approved for treating cancer, take advantage of our developing understanding of the immune system, and harness this knowledge to enhance, or direct, immune responses toward infectious agents.
View Article and Find Full Text PDFA lightweight weed detection model for cotton fields based on an improved YOLOv8n.
Sci Rep
January 2025
College of Information Science and Technology, Gansu Agricultural University, Lanzhou, 730070, China.
In modern agriculture, the proliferation of weeds in cotton fields poses a significant threat to the healthy growth and yield of crops. Therefore, efficient detection and control of cotton field weeds are of paramount importance. In recent years, deep learning models have shown great potential in the detection of cotton field weeds, achieving high-precision weed recognition.
View Article and Find Full Text PDFMagnetic Assisted DNA Logic Gate Nanomachine Based on CRISPR/Cas12a for Recognition of Dual miRNAs.
Chem Asian J
December 2024
Guangxi Normal University, School of chemistry and pharmaceutical science, No.15, Yucai Road, 541004, Guilin, CHINA.
The anomalous expression of microRNA poses a serious threat to human life and health safety, and serves as an important biomarker for cancer detection. In this study, a novel magnetic-assisted DNA logic gate nanomachine triggered by miRNA-21 and miRNA-155 was designed based on the trans-cleavage activity of CRISPR/Cas12a activated by a split DNA activator, using only a single crRNA and signal probe, which simplified the detection procedure and complex nucleic acid amplification. The presence of target molecules, miRNA-21 and miRNA-155, can stimulate the DNA walker machine assembled on magnetic beads, which releases activator under the action of DNAzyme.
View Article and Find Full Text PDFIdentification of novel candidate genes for Ascochyta blight resistance in chickpea.
Sci Rep
December 2024
Department of Plant Sciences, North Dakota State University, Fargo, ND, 58102, USA.
Ascochyta blight, caused by the necrotrophic fungus Ascochyta rabiei, is a major threat to chickpea production worldwide. Resistance genes with broad-spectrum protection against virulent A. rabiei strains are required to secure chickpea yield in the US Northern Great Plains.
View Article and Find Full Text PDFThe UP1 domain is essential for the facilitation effect of HnRNP A1 on PRRSV-2 replication.
Virology
December 2024
Key Laboratory of Veterinary Biological Products, College of Veterinary Medicine, Henan University of Animal Husbandry and Economy, Zhengzhou, 450046, China. Electronic address:
Porcine reproductive and respiratory syndrome virus (PRRSV) infection causes reproductive failure and respiratory distress and is a serious threat to the swine industry, given its continuous and rapid emergence. The knowledge of viral-host interaction could facilitate anti-PRRSV drug development. HnRNP A1 is an abundantly expressed protein which associates with RNA metabolic processes and plays multifarious roles during the reproduction cycle of multiple viruses.
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