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Group A induces CD1a-autoreactive T cells and promotes psoriatic inflammation.
Sci Immunol
June 2023
MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Group A (GAS) infection is associated with multiple clinical sequelae, including different subtypes of psoriasis. Such post-streptococcal disorders have been long known but are largely unexplained. CD1a is expressed at constitutively high levels by Langerhans cells and presents lipid antigens to T cells, but the potential relevance to GAS infection has not been studied.
View Article and Find Full Text PDFA case of acute poststreptococcal glomerulonephritis complicated by interstitial nephritis related to streptococcal pyrogenic exotoxin B.
Pathol Int
March 2022
Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.
This paper presents the case of a patient who developed acute kidney injury and nephrotic syndrome following streptococcal cutaneous infection. He presented with microhematuria, severe proteinuria and systemic edema 5 days after infection. Blood examination showed elevated creatinine level, hypocomplementemia, and elevated anti-streptolysin O level.
View Article and Find Full Text PDFClassic and Non-classic (Surrepticius) Scabies: Diagnostic and Treatment Considerations.
Cureus
March 2020
Dermatology, San Diego Family Dermatology, National City, USA.
The morphology of scabies, a mite infestation of worldwide proportion, is characterized by a variety of cutaneous lesions. Patients with classic scabies present with characteristic burrows often located on the web spaces of the fingers and toes. Scabies surrepticius refers to the non-classic atypical presentation of scabies; establishing the diagnosis of scabies in these individuals can be difficult.
View Article and Find Full Text PDFPoststreptococcal Illness: Recognition and Management.
Am Fam Physician
April 2018
University of Tennessee Family Medicine Residency Program, Jackson, TN, USA.
Group A beta-hemolytic streptococcus can cause several postinfectious, nonsuppurative immune- mediated diseases including acute rheumatic fever, poststreptococcal reactive arthritis, pediatric autoimmune neuropsychiatric disorders, and poststreptococcal glomerulonephritis. Except for sporadic outbreaks, poststreptococcal autoimmune syndromes occur most commonly in sub-Saharan Africa, India, Australia, and New Zealand. Children younger than three years are rarely affected by group A streptococcus pharyngitis or rheumatic fever, and usually do not require testing.
View Article and Find Full Text PDFBackground: Erythema Nodosum (EN) is an acute nodular erythematous cutaneous eruption. It is presumed to be a hypersensitivity reaction and it may be idiopathic, or occur in association with diverse diseases and medications.
Aim: To identify the main etiologies of EN among patients admitted to a medicine service of a clinical hospital.
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