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An Integrative Computational Approach for the Identification of C-Abl Kinase Inhibitors from Anti-Parkinson Plant-Derived Bioactive.
Med Chem
January 2025
Department of Chemistry and Biochemistry, Faculty of Medicine and Pharmacy, Ibn Zohr University, Laayoune 70000, Morocco.
Background: Oxidative stress is strongly linked to neurodegeneration through the activation of c-Abl kinase, which arrests α-synuclein proteolysis by interacting with parkin interacting substrate (PARIS) and aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2). This activation, triggered by ataxia-telangiectasia mutated (ATM) kinase, leads to dopaminergic neuron loss and α-synuclein aggregation, a critical pathophysiological aspect of Parkinson's disease (PD). To halt PD progression, pharmacological inhibition of c-Abl kinase is essential.
View Article and Find Full Text PDFInfection control nurse: A scoping review.
J Educ Health Promot
November 2024
Department of Child Health Nursing, Manipal College of Nursing, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Infection control is a crucial aspect of healthcare delivery aimed at curtailing the spread of infections within healthcare settings. The role of infection control nurses (ICNs) is reported to have a significant contribution in limiting healthcare-associated infections. Scholarly investigations have explored various domains of ICNs.
View Article and Find Full Text PDFTowards an ontology of mental health: Protocol for developing an ontology to structure and integrate evidence regarding anxiety, depression and psychosis.
Wellcome Open Res
November 2024
Centre for Behaviour Change, University College London, London, England, UK.
Background: Research about anxiety, depression and psychosis and their treatments is often reported using inconsistent language, and different aspects of the overall research may be conducted in separate silos. This leads to challenges in evidence synthesis and slows down the development of more effective interventions to prevent and treat these conditions. To address these challenges, the Global Alliance for Living Evidence on aNxiety, depressiOn and pSychosis (GALENOS) Project is conducting a series of living systematic reviews about anxiety, depression and psychosis.
View Article and Find Full Text PDFBibliometric analysis of laryngeal cancer treatment literature (2003-2023).
Heliyon
January 2025
Department of Otolaryngology Head and Neck Surgery, the Second People's Hospital of Shenzhen, the First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong Province, 518035, China.
Background: Despite advancements in medical science, the 5-year survival rate for laryngeal squamous cell carcinoma remains low, posing significant challenges in clinical management. This study explores the evolution of key topics and trends in laryngeal cancer research. Bibliometric and knowledge graph analysis are utilized to assess contributions in treating this carcinoma and to forecast emerging research hotspots that may enhance future clinical outcomes.
View Article and Find Full Text PDFExploring surgeon behavioural factors impacting the quality of care: protocol for a scoping review.
BMJ Open
January 2025
CancerCare Manitoba, Winnipeg, Manitoba, Canada
Introduction: Modern surgery incorporates many aspects of care, including preoperative workup, surgical management and multidisciplinary collaboration to achieve favourable outcomes and high patient satisfaction. Current literature identifies variability in surgical practice and quality of care. The objective of this study is to fill the gap in the literature by identifying modifiable surgeon behavioural factors influencing the quality of care and to identify interventions and policies that modify these factors.
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