The technical toolkit for Caenorhabditis elegans expands to include experimental selection using antibiotic resistance genes.
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Defect-assisted surface modification of a g-CN@WC heterostructure for tetracycline degradation: DFT calculations, degradation pathways, and nematode-based ecological assessment.
Nanoscale
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School of Chemical Engineering, Yeungnam University, Gyeongsan, 38541, South Korea.
Eliminating hazardous antibiotics from aquatic environments has become a major concern in recent years. Tetracycline (TC) compounds pose a challenge for the selective degradation of harmful chemical groups. In this study, we successfully designed carbon vacancies in a gCN@WC (GW) heterostructure for the effective removal of TC pollutants under visible light.
View Article and Find Full Text PDFConfiguration of electrical synapses filters sensory information to drive behavioral choices.
Cell
December 2024
Department of Neuroscience and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06536, USA; Wu Tsai Institute, Yale University, New Haven, CT 06510, USA; Marine Biological Laboratory, Woods Hole, MA 02543, USA; Instituto de Neurobiología, Recinto de Ciencias Médicas, Universidad de Puerto Rico, San Juan 00901, Puerto Rico. Electronic address:
Synaptic configurations underpin how the nervous system processes sensory information to produce a behavioral response. This is best understood for chemical synapses, and we know far less about how electrical synaptic configurations modulate sensory information processing and context-specific behaviors. We discovered that innexin 1 (INX-1), a gap junction protein that forms electrical synapses, is required to deploy context-specific behavioral strategies underlying thermotaxis behavior in C.
View Article and Find Full Text PDFSleep drive is coupled to tissue damage via shedding of Caenorhabditis elegans EGFR ligand SISS-1.
Nat Commun
December 2024
Department of Biology, California State University Northridge, Northridge, CA, USA.
The benefits of sleep extend beyond the nervous system. Peripheral tissues impact sleep regulation, and increased sleep is observed in response to damaging conditions, even those that selectively affect non-neuronal cells. However, the 'sleep need' signal released by stressed tissues is not known.
View Article and Find Full Text PDFStilbene-based fluorescent chemosensor for selective detection of cyanide ion in DMSO medium and its application in cell-imaging, fingerprint, and food sample analysis.
Spectrochim Acta A Mol Biomol Spectrosc
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Cancer Nanomedicine Lab, Department of Zoology, Periyar University, Salem, TN, India.
We designed a new cyanide sensing probe by one-step synthesis and evaluated it using UV-vis and fluorescent techniques. The active moiety of (Z)-3-(4-(methylthio) phenyl)-2-(4-nitrophenyl) acrylonitrile (NCS) demonstrated fluorescence. The probe NCS showed turn-off fluorescence in the presence of cyanide (CN¯), which has a higher selectivity and sensitivity than other anions.
View Article and Find Full Text PDFProton Tunneling Allows a Proton-Coupled Electron Transfer Process in the Cancer Cell.
JACS Au
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Department of Chemistry, University of Antwerp, Antwerp 2020, Belgium.
Proton-coupled electron transfer (PCET) is a fundamental redox process and has clear advantages in selectively activating challenging C-H bonds in many biological processes. Intrigued by this activation process, we aimed to develop a facile PCET process in cancer cells by modulating proton tunneling. This approach should lead to the design of an alternative photodynamic therapy (PDT) that depletes the mitochondrial electron transport chain (ETC), the key redox regulator in cancer cells under hypoxia.
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