AI Article Synopsis
- The study examines how the NS5A protein of hepatitis C virus (HCV) affects resistance to interferon (IFN) treatment and compares differences between genotypes 1b and 2a.
- Both genotypes were found to inhibit IFN-α and other antiviral responses similarly, suggesting no significant differences in their IFN responses.
- The findings imply that other host factors might contribute to the varied IFN treatment outcomes seen in HCV patients, rather than the genotypes alone.
Article Abstract
Interferon (IFN) response rate in hepatitis C virus (HCV) patients has been varied with genotypes. In this study, we investigated the effects of HCV NS5A protein on IFN resistance and compared the genotypic differences of NS5A. We showed that IFN-α-, poly I:C-, and Sendai virus-induced ISRE transcriptional activities were inhibited by both genotype 1b and 2a NS5A protein. We demonstrated that not only genotype 1b but also genotype 2a NS5A exerted the similar extent of IFN-α-induced antiviral activity. We showed that NS5A derived from both genotype 1b and 2a showed no significant differential IFN responses as seen in HCV patients. These data imply that some other host factor may be involved in genotypic differences of IFN antagonism in HCV patients.
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| http://dx.doi.org/10.1016/j.febslet.2010.08.032 | DOI Listing |
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