We describe symptoms and physical findings consistent with acute or subacute radicular lesions in the lower limb: radicular pain syndromes in the leg and the motor as well as sensory deficits of lumbar and sacral roots L2 to S1. We emphasize the importance of anterior thigh pain which is not sufficiently known, and we point out our neurological findings which do not correspond to descriptions in standard textbooks. Aids to the examination of these radicular syndromes are given, stressing the technique of examining motor signs. We also discuss the differential diagnosis to other, nonradicular syndromes and we present practical guidelines. Finally, surgical emergencies of practical importance are pointed out.
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Gac Med Mex
January 2025
Laboratorio de Reprogramación Celular y Enfermedades Crónico-Degenerativas, Department of Physiology, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Progressive supranuclear palsy (PSP) is a rare, atypical parkinsonism, characterized by the presence of intracerebral tau protein aggregates and determined by a wide spectrum of clinical features. The definitive diagnosis is postmortem and is identified through the presence of neuronal death, gliosis, and aggregates of the tau protein presented in the form of neurofibrillary tangles (MNF) with a globose appearance in regions such as the subthalamic nucleus, the substantia nigra, and the globus pallidus The findings in ancillary imaging studies, as well as fluids biomarkers, are not sufficient to support diagnosis of PSP but are used to rule out similar pathologies because there are still no specific or validated biomarkers for this disease. The current treatment of PSP is focused on reducing symptoms, although emerging therapies seek to counteract its pathophysiological mechanisms.
View Article and Find Full Text PDFJ Infect Dev Ctries
December 2024
University Clinic for Infectious and Tropical Diseases of the University Clinical Centre of Serbia, Belgrade, Serbia.
Introduction: Bilateral facial nerve palsy (FNP) is a rare condition that is idiopathic in only 20%. FNP is the most common cranial neuropathy in West Nile neuroinvasive disease (WNND) but is usually unilateral and only a few cases of bilateral FNP have been reported.
Case: We present a case of a 65-year-old woman with confirmed WNND and simultaneous bilateral FNP.
Discov Oncol
January 2025
Department of General Surgery, Tianjin Fifth Central Hospital, No. 41 Zhejiang Road, Binhai New Area, Tianjin, 300450, China.
Gastric cancer (GC), a prevalent malignancy worldwide, encompasses a multitude of biological processes in its progression. Recently, ferroptosis, a novel mode of cell demise, has become a focal point in cancer research. The microenvironment of gastric cancer is composed of diverse cell populations, yet the specific gene expression profiles and their association with ferroptosis are not well understood.
View Article and Find Full Text PDFRev Esp Enferm Dig
January 2025
Gastroenterology, The First Affiliated Hospital. Zhejiang University School of Medicine, China.
Ménétrier's disease is a rare gastritis. Although there were some pathological features under gastroscopy, the depth of mucosal infiltration observed was not enough, and it was difficult to distinguish from other gastric mucosal lesions. A biopsy guided by gastroscopy is not deep enough and may lead to misdiagnosis due to incomplete sampling of the entire gastric mucosa.
View Article and Find Full Text PDFRev Esp Enferm Dig
January 2025
Gastroenterology and Hepatology, Hospital Universitario Virgen de las Nieves, España.
Hereditary haemorrhagic telangiectasia (HHT) is a rare genetic disease characterised by mucocutaneous telangiectasias and arteriovenous malformations that can affect multiple organs. Although rare, ischaemic cholangiopathy can occur, a serious complication that can even lead to death. We present the case of a patient with HHT disease with previous mucocutaneous and gastrointestinal manifestations in whom 8 weeks after cholecystectomy a saccular dilatation of the intrahepatic bile duct was observed.
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