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A fluorescence and colorimetric dual-mode aptasensor for kanamycin detection.
Biosens Bioelectron
January 2025
Department of Chemistry, University of Otago, Dunedin, 9016, New Zealand. Electronic address:
This study presents the development of a dual-mode aptasensor for the sensitive detection of kanamycin (KAN), utilizing both fluorescence and colorimetric signals. The aptasensor was constructed using amino-functionalized silica nanoparticles (SiO) combined with copper nanoclusters (CuNCs) and DNA-templated silver nanoclusters (DNA-AgNCs). Encapsulating CuNCs within SiO (CuNCs@SiO) enhanced their stability by shielding them from environmental interference, while maintaining their bright blue fluorescence as a reference signal.
View Article and Find Full Text PDFSwitchable and orthogonal gene expression control inside artificial cells by synthetic riboswitches.
Chem Commun (Camb)
June 2024
Earth-Life Science Institute, Tokyo Institute of Technology, Ookayama 2-12-1, Meguro-Ku, Tokyo 152-8550, Japan.
Here we report two novel synthetic riboswitches that respond to ASP2905 and theophylline and function in reconstituted cell-free protein synthesis (CFPS) system. We encapsulated the CFPS system as well as DNA-templated encoding reporter genes regulated by these orthogonal riboswitches inside liposomes, and achieved switchable and orthogonal control over gene expression by external stimulation with the cognate ligands.
View Article and Find Full Text PDFPlasmon-emitter coupling in cytosine-rich hairpin DNA-templated silver nanoclusters: Thermal reversibility, white light emission, and dynamics inside live cells.
J Chem Phys
April 2024
Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhopal 462066, Madhya Pradesh, India.
Bio-templated luminescent noble metal nanoclusters (NCs) have attracted great attention for their intriguing physicochemical properties. Continuous efforts are being made to prepare NCs with high fluorescence quantum yield (QY), good biocompatibility, and tunable emission properties for their widespread practical applications as new-generation environment-friendly photoluminescent materials in materials chemistry and biological systems. Herein, we explored the unique photophysical properties of silver nanoclusters (AgNCs) templated by cytosine-rich customized hairpin DNA.
View Article and Find Full Text PDFPro-Apoptotic Activity of -Obtusane against Cervical Cancer: Nano Formulation, In Silico Molecular Docking, and Pharmacological Network Analysis.
Pharmaceuticals (Basel)
November 2023
Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Universities Zone, New Minia 61111, Egypt.
Cancer is a major disease that threatens human health all over the world. Intervention and prevention in premalignant processes are successful ways to prevent cancer from striking. On the other hand, the marine ecosystem is a treasure storehouse of promising bioactive metabolites.
View Article and Find Full Text PDFHydrogel-Encapsulated Beads Enable Proximity-Driven Encoded Library Synthesis and Screening.
ACS Cent Sci
August 2023
Department of Pharmaceutical Sciences, University of California, Irvine, California 92697, United States.
Encoded combinatorial library technologies have dramatically expanded the chemical space for screening but are usually only analyzed by affinity selection binding. It would be highly advantageous to reformat selection outputs to "one-bead-one-compound" solid-phase libraries, unlocking activity-based and cellular screening capabilities. Here, we describe hydrogel-encapsulated magnetic beads that enable such a transformation.
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