Little is known mechanistically about why implanted glucose sensors lag behind blood glucose levels in both the time to peak sensor response and the magnitude of peak sensor response. A mathematical model of glucose transport from capillaries through surrounding tissue to the sensor surface was constructed to address how different aspects of the tissue affect glucose transport to an implanted sensor. Physiologically relevant values of capsule diffusion coefficient, capsule porosity, cellular glucose consumption, capsule thickness, and subcutaneous vessel density were used as inputs to create simulated sensor traces that mimic experimental instances of time lag and concentration attenuation relative to a given blood glucose profile. Using logarithmic sensitivity analysis, each parameter was analyzed to study the effect of these variables on both lag and attenuation. Results identify capsule thickness as the strongest determinant of sensor time lag, while subcutaneous vessel density and capsule porosity had the largest effects on attenuation of glucose that reaches the sensor surface. These findings provide mechanistic insight for the rational design of sensor modifications that may alleviate the deleterious consequences of tissue effects on implanted sensor performance.
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http://dx.doi.org/10.1007/s00216-010-4097-6 | DOI Listing |
Cureus
December 2024
Emergency, Royal Victorian Eye and Ear Hospital, Melbourne, AUS.
Idiopathic intracranial hypertension (IIH) is a neurological disorder characterized by chronic headaches, cognitive difficulties, reduced quality of life, and rarely irreversible visual loss. Community diagnosis is often challenging due to unfamiliarity with current guidelines and a lack of clinical experience, leading to misdiagnosis and treatment delays, which can negatively impact visual recovery and quality of life. Our study examined the time to diagnosis and investigated the barriers to timely diagnosis in adults with newly diagnosed IIH.
View Article and Find Full Text PDFHeliyon
January 2025
School of Architecture, Tianjin University, 300072, Tianjin, China.
Air pollution has become a major challenge to global urban sustainable development, necessitating urgent solutions. Meteorological variables are key determinants of air quality; however, research on their impact across different urban gradients remains limited, and their mechanisms are largely unexplored. This study investigates the dynamic effects of meteorological variables on air quality under varying levels of urbanization using Kaohsiung City, Taiwan, as a case study.
View Article and Find Full Text PDFHealth Psychol Behav Med
January 2025
Department of Psychology, Faculty of Psychology, Universitas Padjadjaran, Sumedang, Indonesia.
Background: Psychologists play a crucial role in providing essential psychological aid to individuals navigating the challenges posed by the COVID-19 pandemic. However, studies focusing on the mental health of psychologists during the COVID-19 pandemic remain scarce. This study investigates the interaction between coping strategies and psychological distress among a group of Indonesian psychologists.
View Article and Find Full Text PDFInt J Environ Health Res
January 2025
School of Geosciences, University of South Florida, Tampa, FL, USA.
The geographical distribution of Lyme disease has been attributed to changes in Earth's climate and associated distribution of its vector, ticks of the genus . This study focuses on the impact of climatic and meteorological conditions on Lyme disease transmission in East Central Ohio, an emerging hotspot of cases. Using county-level data from 2001 to 2023, we analyzed the relationship between Lyme disease cases and temperature, precipitation, and the Southern Oscillation Index (SOI) using a distributed lag nonlinear model (DLNM).
View Article and Find Full Text PDFDoc Ophthalmol
January 2025
Department of Ophthalmology and Visual Sciences, Research Institute of the McGill University Health Centre/Montreal Children's Hospital, 1001 Décarie Boulevard, Glen Site, Block E, Office #EM03238, Montréal, QC, H4A 3J1, Canada.
Purpose: Study the scotopic oscillatory potentials (OPs) in mice over a wide range of flash luminance levels using the Hilbert transform (HT) to extract new features of the high frequency components of the electroretinogram (ERG).
Methods: Scotopic ERGs [Intensity: - 6.3 to 0.
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