We report a case of an immunocompetent Peruvian patient from the Andes with a one-month history of meningoencephalitis. Cryptococcus gattii was identified from a cerebrospinal fluid culture through assimilation of D-proline and D-tryptophan as the single nitrogen source. Initially, the patient received intravenous antifungal therapy with amphotericin B. The patient was discharged 29 days after hospitalization and continued with oral fluconazole treatment for ten weeks. During this period, the patient showed clinical improvement with slight right-side residual weakness. Through this case report, we confirm the existence of this microorganism as an infectious agent in Peru.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1590/s0037-86822010000400029 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Lack of TLR9 exacerbates ocular impairment and visual loss during systemic Cryptococcus gattii infection.
J Infect Dis
January 2025
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil.
Cryptococcus gattii is a saprophytic basidiomycete that grows in the environment and can cause systemic cryptococcosis. Ocular cryptococcosis causes blindness and is commonly associated with central nervous system (CNS) infection. Toll-like receptor 9 (TLR9) can control cryptococcosis and another mycosis.
View Article and Find Full Text PDFPredictors of Cryptococcus gattii clinical presentation and outcome: An international study.
Clin Infect Dis
January 2025
Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Background: Infection by Cryptococcus gattii can lead to pulmonary or central nervous system (CNS) disease, or both. Whether site of infection and disease severity are associated with C. gattii species and lineages or with certain underlying medical conditions, or both is unclear.
View Article and Find Full Text PDFEarly Onset of Post-Infectious Inflammatory Response Syndrome (PIIRS) in a Previously Healthy, HIV-Negative Paediatric Patient With Cryptococcus gattii Meningitis: A Case Report.
J Paediatr Child Health
January 2025
Infection Management, QCH and CHQ Clinical Unit, The University of Queensland, South Brisbane, Queensland, Australia.
Divergent paths: gene evolution in Cryptococcus and implications for pathogenicity.
Curr Med Mycol
April 2024
Department of Biotechnology, College of Science, University of Anbar, Ramadi, Anbar, Iraq.
Background And Purpose: and are highly virulent species that cause diseases, such as meningoencephalitis and pulmonary infections. The gene predominantly determines the virulence of the pathogenic species. This study aimed to examine in both pathogenic and non-pathogenic species.
View Article and Find Full Text PDFAn immunoinformatics and extensive molecular dynamics study to develop a polyvalent multi-epitope vaccine against cryptococcosis.
PLoS One
December 2024
Faculty of Biotechnology and Genetic Engineering, Sylhet Agricultural University, Sylhet, Bangladesh.
Cryptococcosis is a lethal mycosis instigated by the pathogenic species Cryptococcus neoformans and Cryptococcus gattii, primarily affects the lungs, manifesting as pneumonia, and the brain, where it presents as meningitis. Mortality rate could reach 100% if infections remain untreated in cryptococcal meningitis. Treatment options for cryptococcosis are limited and and there are no licensed vaccines clinically available to treat or prevent cryptococcosis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!