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Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance. | LitMetric

AI Article Synopsis

Article Abstract

Quinolone antibacterials have been used to treat bacterial infections for over 40 years. A crystal structure of moxifloxacin in complex with Acinetobacter baumannii topoisomerase IV now shows the wedge-shaped quinolone stacking between base pairs at the DNA cleavage site and binding conserved residues in the DNA cleavage domain through chelation of a noncatalytic magnesium ion. This provides a molecular basis for the quinolone inhibition mechanism, resistance mutations and invariant quinolone antibacterial structural features.

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Source
http://dx.doi.org/10.1038/nsmb.1892DOI Listing

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