AI Article Synopsis
- The detection of carbapenemases in Gram-negative bacilli is crucial for effective patient treatment and managing antibiotic resistance.
- The study found that using MacConkey agar improved the performance of the modified Hodge test for identifying carbapenemase-producing bacteria compared to Mueller-Hinton agar, as it releases β-lactamases more effectively.
- Additionally, the modified Hodge test helps clarify issues related to ambiguous results from double-disk synergy tests for metallo-β-lactamase detection.
Article Abstract
The detection of carbapenemases in Gram-negative bacilli is important for optimal patient treatment and to control spread of the resistance. The modified Hodge test can detect carbapenemase-producing Gram-negative bacilli. In this study, we compared the performance of MacConkey agar and Mueller-Hinton agar for metallo-β-lactamase (MBL) and OXA carbapenemase screening. Overall, the performance of Hodge test was better with MacConkey agar due to enhanced release of β-lactamases from the cells in the presence of bile compounds. Concomitant use of the modified Hodge test could resolve most of the problems with uncertain double-disk synergy tests in MBL detection.
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| http://dx.doi.org/10.1016/j.mimet.2010.08.010 | DOI Listing |
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