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Cysteine-based redox switches in enzymes. | LitMetric

Cysteine-based redox switches in enzymes.

Antioxid Redox Signal

Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

Published: March 2011

AI Article Synopsis

Article Abstract

The enzymes involved in metabolism and signaling are regulated by posttranslational modifications that influence their catalytic activity, rates of turnover, and targeting to subcellular locations. Most prominent among these has been phosphorylation/dephosphorylation, but now a distinct class of modification coming to the fore is a set of versatile redox modifications of key cysteine residues. Here we review the chemical, structural, and regulatory aspects of such redox regulation of enzymes and discuss examples of how these regulatory modifications often work in concert with phosphorylation/dephosphorylation events, making redox dependence an integral part of many cell signaling processes. Included are the emerging roles played by peroxiredoxins, a family of cysteine-based peroxidases that now appear to be major players in both antioxidant defense and cell signaling.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064533PMC
http://dx.doi.org/10.1089/ars.2010.3376DOI Listing

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