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An up-to-date review of biomedical applications of serratiopeptidase and its biobetter derivatives as a multi-potential metalloprotease.
Arch Microbiol
March 2024
New Technologies Research Group, Nanobiotechnology Department, Pasteur Institute of Iran, Tehran, Iran.
Serratiopeptidase is a bacterial metalloprotease used in a variety of medical applications. The multidimensional properties of serratiopeptidase make it noticeable as a miraculous enzyme. Anti-coagulant, anti-inflammatory and anti-biofilm activity of serratiopeptidase making it useful in reducing pain and swelling associated with various conditions including arthritis, diabetes, cancer, swelling, pain and also thrombolytic disorders.
View Article and Find Full Text PDFMultiplexed detection of biomarkers using a microfluidic chip integrated with mass-producible micropillar array electrodes.
Anal Chim Acta
September 2023
School of Science, Harbin Institute of Technology, Shenzhen, Shenzhen, 518055, PR China; School of Mechanical Engineering and Automation, Harbin Institute of Technology, Shenzhen, Shenzhen, 518055, PR China; Center for Microflows and Nanoflows, Harbin Institute of Technology, Shenzhen, Shenzhen, 518055, PR China. Electronic address:
Quantifying multiple biomarkers with high sensitivity in tiny biological samples is essential to meet the growing demand for point-of-care testing. This paper reports the development of a novel microfluidic device integrated with mass-producible micropillar array electrodes (μAEs) for multiple biomarker detections. The μAE are mass-fabricated by soft lithography and hot embossing technique.
View Article and Find Full Text PDFIdentification of differentially expressed autophagy genes associated with osteogenic differentiation in human bone marrow mesenchymal stem cells.
Am J Transl Res
August 2022
Department of Orthopaedic Surgery, Honghui Hospital, Xi'an Jiaotong University Xi'an 710054, Shaan'xi Province, China.
Background: Mesenchymal stem cells derived from human tissues have been widely used for tissue regeneration because of their strong self-renewal capacity and multi-potential properties. Autophagy plays a vital role in maintaining bone homeostasis. However, the mechanism underlying this role for autophagy in the osteogenic differentiation of mesenchymal stem cells remains to be elucidated.
View Article and Find Full Text PDFTransplantation of Exercise-Induced Extracellular Vesicles as a Promising Therapeutic Approach in Ischemic Stroke.
Transl Stroke Res
April 2023
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Daneshjoo Blvd., Chamran Hwy., PO: 19615-1178, Tehran, Iran.
Clinical evidence affirms physical exercise is effective in preventive and rehabilitation approaches for ischemic stroke. This sustainable efficacy is independent of cardiovascular risk factors and associates substantial reprogramming in circulating extracellular vesicles (EVs). The intricate journey of pluripotent exercise-induced EVs from parental cells to the whole-body and infiltration to cerebrovascular entity offers several mechanisms to reduce stroke incidence and injury or accelerate the subsequent recovery.
View Article and Find Full Text PDFA novel nano therapeutic using convalescent plasma derived exosomal (CP) for COVID-19: A combined hyperactive immune modulation and diagnostics.
Chem Biol Interact
August 2021
Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
Extracellular vesicles like exosomes are important therapeutic tactics for treating COVID -19. By utilizing convalescent plasma derived exosomes (CP) from COVID-19 recovered persistence could accelerate the treatment strategies in the current state of affairs. Adequate literature has shown that administering the exosome to the in vivo system could be beneficial and could target the pathogens in an effective and precise manner.
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