AI Article Synopsis
- The study investigates the development of tau protein formation in a specific mouse model of Alzheimer's disease (3xTg-AD mice) that carry human genetic mutations related to the disease.
- Early signs of tau-related proteins were detected in specific brain areas (like the amygdala and hippocampus) as early as 3 weeks of age, with changes progressing into the cortex as the mice got older.
- The findings suggest that multiple biochemical processes, aside from the early accumulation of tau and other proteins, contribute to the later formation of tau filaments as the mice age.
Article Abstract
The age-related pathological cascade underlying intraneuronal tau formation in 3xTg-AD mice, which harbor the human APP(Swe), PS1(M126V) , and Tau(P301L) gene mutations, remains unclear. At 3 weeks of age, AT180, Alz50, MC1, AT8, and PHF-1 intraneuronal immunoreactivity appeared in the amygdala and hippocampus and at later ages in the cortex of 3xTg-AD mice. AT8 and PHF-1 staining was fixation dependent in young mutant mice. 6E10 staining was seen at all ages. Fluorescent immunomicroscopy revealed CA1 neurons dual stained for 6E10 and Alz50 and single Alz50 immunoreactive neurons in the subiculum at 3 weeks and continuing to 20 months. Although electron microscopy confirmed intraneuronal cytoplasmic Alz50, AT8, and 6E10 reaction product in younger 3xTg-AD mice, straight filaments appeared at 23 months of age in female mice. The present data suggest that other age-related biochemical mechanisms in addition to early intraneuronal accumulation of 6E10 and tau underlie the formation of tau filaments in 3xTg-AD mice.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925282 | PMC |
| http://dx.doi.org/10.4061/2010/780102 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!