AI Article Synopsis
- The karlotoxins (KmTxs) are toxic compounds produced by the dinoflagellate Karlodinium veneficum that disrupt cell membranes.
- KmTx 1 has a structure revealed by 2D NMR spectroscopy that closely resembles other similar toxins but has unique modifications in its core region.
- Unlike KmTx 2, KmTx 1 does not have chlorination at its terminal alkene and has a hydrophobic arm that is longer by two carbon atoms.
Article Abstract
The karlotoxins (KmTxs) are a family of compounds produced by the dinoflagellate Karlodinium veneficum that cause membrane permeabilization. The structure of KmTx 1, determined using extensive 2D NMR spectroscopy, is very similar to the amphidinols and related compounds, though KmTx 1 features unique structural modifications of the conserved core region. The structure of KmTx 1 differs from that reported for KmTx 2, the only other reported karlotoxin to date, in lacking chlorination at its terminal alkene and possessing a hydrophobic arm that is two carbons longer.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928153 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2008.08.103 | DOI Listing |
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