The article discusses the results of treatment of 7,092 patients with purulent wounds and septic surgical diseases by means of a suggested method of active surgical management. The main principles of the method are as follows: preoperative examination and preparation of the patients for operation for 12-36 hours; radical excision of all purulent and nonviable tissues followed by active drainage and treatment under conditions of controlled abacterial medium or by ointments on a water-soluble base; use of auxiliary methods for the treatment of the wound surface (pulsed stream of antiseptics, ultrasonic cavitation, vacuum treatment); performance of laboratory tests (microbial dissemination per 1 g tissue, cytologic and morphologic studies, values of tissue hemostasis) as an objective criterion of the course of the wound process and for determining whether the wound surface is ready for closure; accomplishment of intensive therapy; early closure of the wound surface with sutures or by plastic operations. Analysis of the data allows the conclusions that active surgical treatment may be accepted as an optimal and universal method for the management of purulent wounds of any etiology and septic surgical diseases. With its application, the terms of treatment are shortened due to most economical mechanisms of healing by first intention, and good functional and cosmetic results are produced. Such an effect is due to the pathogenetic character of all components of the method.
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J Dermatolog Treat
December 2025
Department of Dermatology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, P.R. China.
Aim: Verruca vulgaris is a common skin disease among children. Foreign object mimicking a wart is unusual.
Methods: A report of a 6-year-old boy with foreign object misdiagnosed as verruca vulgaris.
Biomacromolecules
January 2025
Institute of Surface Engineering (IOM), Permoserstraße 15, 04318 Leipzig, Germany.
Hybrid hydrogels are promising for wound dressing, tissue engineering, and drug delivery due to their exceptional biocompatibility and mechanical stability. This study synthesized hybrid hydrogels for photodynamic therapy using electron beam-initiated polymerization with varying PEGDA/gelatin ratios and irradiation doses to evaluate their effectiveness as uptake and release systems for five photosensitizers. Toluidine blue, O (TBO); methylene blue (MB); eosin, Y; indocyanine, green; and sodium meso-tetraphenylporphine-4,4',4″,4‴-tetrasulfonate were studied for their uptake and release dynamics in relation to their structural properties and the hydrogels' composition.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Department of Materials Engineering, Taiyuan Institute of Technology, Taiyuan 030008, China. Electronic address:
Bacterial infections have become a fatal issue for human health. The excessive use of antibiotics leads to bacterial resistance. It is of great importance to develop alternate antimicrobial nanomaterials for effective antibacterial therapy.
View Article and Find Full Text PDFExp Eye Res
January 2025
Laboratory of Ocular Immunology, Transplantation and Regeneration, Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA. Electronic address:
Substance P (SP) expressed by corneal nerves, is an 11-amino acid long neuropeptide from the tachykinin family, encoded by the Tac1 gene, and binds to neurokinin receptors. SP overexpression is associated with various pathological responses in the cornea including vasodilation, pain, inflammation, and angiogenesis in the normally avascular tissue. This study investigates the role of neurokinin-1 receptor (NK-1R) mediated signaling in nociception, nerve regeneration, and neuronal activation following mechanical corneal injury in mice.
View Article and Find Full Text PDFPLoS One
January 2025
Faculty of Health, University of Canterbury, Christchurch, Canterbury, New Zealand.
The incidence of head impacts in rugby has been a growing concern for player safety. While rugby headgear shows potential to mitigate head impact intensity during laboratory simulations, evaluating its on-field effectiveness is challenging. Current rugby-specific laboratory testing methods may not represent on-field conditions.
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