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Advances in bacterial glycoprotein engineering: A critical review of current technologies, emerging challenges, and future directions.
Biotechnol Adv
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TEDA Institute of Biological Sciences and Biotechnology, Tianjin Key Laboratory of Microbial Functional Genomics, Nankai University, Tianjin, PR China; Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin, PR China; Nankai International Advanced Research Institute, Nankai University, Shenzhen, China. Electronic address:
Protein glycosylation, which involves the addition of carbohydrate chains to amino acid side chains, imparts essential properties to proteins, offering immense potential in synthetic biology applications. Despite its importance, natural glycosylation pathways present several limitations, highlighting the need for new tools to better understand glycan structures, recognition, metabolism, and biosynthesis, and to facilitate the production of biologically relevant glycoproteins. The field of bacterial glycoengineering has gained significant attention due to the ongoing discovery and study of bacterial glycosylation systems.
View Article and Find Full Text PDFPrecision tumor treatment utilizing bacteria: principles and future perspectives.
Appl Microbiol Biotechnol
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Department of Ultrasound Medicine, The Second Affiliated Hospital of Air Force Medical University, No.569 Xinsi Road, Xi'an, 710038, Shaanxi, China.
Bacteria-based tumor therapy, which releases therapeutic payloads or remodels the tumor's immune-suppressive microenvironment and directly kills tumor cells or initiates an anti-tumor immune response, is recently recognized as a promising strategy. Bacteria could be endowed with the capacities of tumor targeting, tumor cell killing, and anti-tumor immune activating by established gene engineering. Furthermore, the integration of synthetic biology and nanomedicine into these engineered bacteria could further enhance their efficacy and controllability.
View Article and Find Full Text PDFA Zero-gap Electrolyzer Enables Supporting Electrolyte-free Seawater Splitting for Energy-saving Hydrogen Production.
Angew Chem Int Ed Engl
January 2025
Chinese Academy of Sciences Qingdao Industrial Energy Storage Technology Institute, Department of Energy Science and Energy Technology, Songling Road, 189, 266101, Qingdao City, CHINA.
Membrane-assisted direct seawater splitting (DSS) technologies are actively studied as a promising route to produce green hydrogen (H2), whereas the indispensable use of supporting electrolytes that help to extract water and provide electrochemically-accelerated reaction media results in a severe energy penalty, consuming up to 12.5% of energy input when using a typical KOH electrolyte. We bypass this issue by designing a zero-gap electrolyzer configuration based on the integration of cation exchange membrane and bipolar membrane assemblies, which protects stable DSS operation against the precipitates and corrosion in the absence of additional supporting electrolytes.
View Article and Find Full Text PDFOpportunities and challenges of bacterial extracellular vesicles in regenerative medicine.
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Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong, China.
Extracellular vesicles (EVs) are membrane-bound vesicles that are shed or secreted from the cell membrane and enveloped by a lipid bilayer. They possess stability, low immunogenicity, and non-cytotoxicity, exhibiting extensive prospects in regenerative medicine (RM). However, natural EVs pose challenges, such as insufficient targeting capabilities, potential biosafety concerns, and limited acquisition pathways.
View Article and Find Full Text PDFHuman Epidermal Growth Factor Receptor 2 Positive Advanced Gastric or Esophagogastric Adenocarcinoma: Reflecting on the Past to Gain a New Insights.
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Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa City, Chiba, Japan.
Purpose Of Review: Human epidermal growth factor receptor 2 (HER2) is a critical target in advanced gastric cancer (AGC). This review highlights the current treatment landscape, lessons learned from past clinical trials, and prospects for future treatment strategies for HER2-positive AGC.
Recent Findings: Trastuzumab had been the standard treatment for HER2-positive AGC for a decade, and subsequently, trastuzumab deruxtecan, an antibody-drug conjugate (ADC), emerged with an impressive response.
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