Six new linear polyacetylenic C25 and C27 acetogenins (1-6), named debilisones A-F, have been isolated from a methanol extract of roots of Polyalthia debilis. Structures of these compounds were determined by spectroscopic techniques. The absolute configuration at C-17 of 2 was assigned by the modified Mosher's method. Compounds 2, 3, and 5 exhibited moderate antimycobacterial activity against Mycobacterium tuberculosis with MIC values of 25.0, 12.5, and 25.0 microg/mL, respectively.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/np1001913 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Green Synthesis of Copper Nanoparticles Using Roots and their Bioactivities Against , and .
J Pharm Bioallied Sci
July 2024
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia.
The synthesis of copper nanoparticles (CuNPs) has been the center of researchers' attention due to their potential in various fields, particularly in medicine and pharmacy. The objective of this research was to synthesize CuNPs by using the extract from longifolia roots via an organic solvent-free approach. The roots of were extracted using boiling water and subsequently used to synthesize CuNPs from CuSO solution.
View Article and Find Full Text PDFNephroprotective potential of roots against vancomycin-induced renal toxicity in experimental animals.
Front Pharmacol
January 2023
Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia.
This study was done to investigate the possible nephroprotective effect of an ethanolic root extract of (PL) on vancomycin-induced nephrotoxicity using curative and protective models. Vancomycin (150 mg/kg, intravenous) was given to healthy Wistar albino rats in the curative model before the start of treatment, whereas the protective group received vancomycin at the conclusion of the 10-day treatment procedure. Animals were divided into six groups for both models; group I served as the normal control, while groups II, III, IV, V, and VI were kept as toxic control, standard (selenium, 6 mg/kg), LDPL (low dose of PL 200 mg/kg), HDPL (high dose of PL 400 mg/kg), and HDPL + selenium (interactive) groups, respectively.
View Article and Find Full Text PDFA comprehensive review on medicinal plants possessing antioxidant potential.
Clin Exp Pharmacol Physiol
March 2023
Department of Eastern Medicine, Jinnah University for Women, Karachi, Pakistan.
Many research studies have proposed that about two-thirds of the medicinal plant species of the world possess significant antioxidant potential. Antioxidants are very beneficial as they decrease oxidative stress (OS) in cells and hence play their role in management as well as treatment of numerous diseases like cancers, cardiovascular diseases, as well as many inflammatory illnesses. This review comprises the antioxidant potential of numerous parts of medicinal plants like leaves, stems, roots, seeds, fruits, as well as bark.
View Article and Find Full Text PDF3,4- seco-Norclerodane Diterpenoids from the Roots of Polyalthia laui.
J Nat Prod
January 2019
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University, Haikou 571158 , People's Republic of China.
Ten new clerodane diterpenoids, polylauioids A-J (1-10), and five known analogues (11-15) were isolated from the roots of Polyalthia laui. Among the new compounds, 3 and 8 are artifacts. The structures were elucidated using spectroscopic methods and by comparison with published NMR spectroscopic data.
View Article and Find Full Text PDFA new norsesquiterpene from the roots of Polyalthia laui.
Nat Prod Res
July 2017
a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou , China.
One new norsesquiterpene polyalone A (1), and one new natural product 9-keto-cyclocolorenone (2), along with three known analogues (3-5) were isolated from the roots of Polyalthia laui. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. All compounds were evaluated for their cytotoxic activities and antibacterial activities.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!