A highly efficient synthesis of hydantoins has been developed from simple and commercially available 1,3-dicarbonyl compounds, ureas, and methyl ketones or terminal aryl alkenes. This protocol involves a sustainable integration of two coupled domino processes: iodine-promoted synthesis of unsymmetrical 1,4-enediones (domino I) and the sequential transformation into hydantoins (domino II).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol1015948 | DOI Listing |
Publication Analysis
Top Keywords
efficient synthesis
8
synthesis hydantoins
8
sustainable integration
8
integration coupled
8
coupled domino
8
domino processes
8
hydantoins sustainable
4
domino
4
processes highly
4
highly efficient
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!