The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r(1) relaxivity of ∼48 mM(-1) s(-1) is shown to enhance MR images of tumors grown in mice in vivo.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967214 | PMC |
| http://dx.doi.org/10.1021/ja105563a | DOI Listing |
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