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| http://dx.doi.org/10.1136/bmj.1.4968.660 | DOI Listing |
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In vitro photodynamic therapy of Candida albicans, the cause of vulvovaginal candidiasis, is enhanced by Bacillus and Enterococcus probiotics.
Photodiagnosis Photodyn Ther
January 2025
Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran. Electronic address:
Background: Candida albicans is the primary cause of vulvovaginal candidiasis, a worldwide health concern for women. The use of supplemental methods, such as antimicrobial photodynamic therapy (aPDT) and probiotics, was promoted by the ineffectiveness of the existing antifungal drugs.
Methods: This study examines the combined effects of probiotics (Bacillus and Enterococcus isolated from the fermented pickles) and PDT (using red laser (655 nm, 18 J/cm) as a light source and methylene blue dye (30 mg/mL) as a photosensitizer) on the in vitro virulence activity of C.
Efficacy and Molecular Mechanisms of Nystatin Against on Postharvest Table Grape.
Foods
November 2024
College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China.
The primary cause of postharvest loss in table grape fruit is attributed to gray mold, which is caused by . The present study confirmed the inhibitory effects of nystatin on the growth and development of , which led to a remarkable reduction in the severity of gray mold on table grape fruits. Furthermore, the application of nystatin disrupted the membrane permeability of , causing increased cellular leakage and cell death.
View Article and Find Full Text PDFMultidrug-resistant keratinolytic dermatophytes and non-dermatophytes causing onychomycosis in outpatients.
Future Microbiol
November 2024
Department of Genetic Engineering & Biotechnology, School of Life Sciences, Shahjalal University of Science and Technology, Sylhet, Bangladesh.
Aims: This study identified and determined antibiograms of keratinolytic dermatophytes (DM), non-dermatophytic molds (NDM), and yeasts causing onychomycosis.
Methods: Morphological, cultural, and biochemical characteristics were used to identify DM and NDM. The keratinolytic activity (KA) and antibiograms were conducted with keratin azure and the agar diffusion method, respectively.
Synergistic potential of Bauhinia holophylla leaf extracts with conventional antifungals in the inhibition of Candida albicans: A new approach for the treatment of oral candidiasis.
Arch Oral Biol
November 2024
Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS 79804-970, Brazil; Faculty of Biological and Environmental Sciences, Federal University of Grande Dourados, Dourados, MS 79804-970, Brazil. Electronic address:
Objective: This study investigated the combination of Bauhinia holophylla (Bong.) Steud. leaf extracts with conventional antifungal agents, highlighting the extracts' potential as adjuvants in treating oral candidiasis.
View Article and Find Full Text PDFMoxidectin elevates Candida albicans ergosterol levels to synergize with polyenes against oral candidiasis.
Appl Microbiol Biotechnol
November 2024
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu, 610041, China.
Article Synopsis
- - Candida albicans is a common fungus that causes oral candidiasis, especially in vulnerable populations like the elderly and those with weakened immune systems, leading to challenges due to drug resistance and side effects of current treatments.
- - Researchers found that moxidectin, an antiparasitic drug, enhances the effectiveness of existing antifungal drugs called polyenes by activating the ergosterol biosynthesis pathway in Candida albicans, which is crucial for the fungi's survival.
- - In experiments, moxidectin combined with low doses of polyenes significantly reduced Candida albicans infection and inflammation in a mouse model, indicating its potential as a promising treatment option in clinical practice.
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