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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2285234 | PMC |
| http://dx.doi.org/10.1136/bmj.2.4320.509 | DOI Listing |
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Objective: The aim of this study was to investigate the role of ferroptosis in the occurrence of postoperative cognitive dysfunction (POCD) using a mouse model and to elucidate whether electroacupuncture (EA) can improve POCD by suppressing ferroptosis via the transferrin receptor 1 (TFR1)-divalent metal transporter 1 (DMT1)-ferroportin (FPN) pathway.
Methods: The experiment involved three groups: the control group, the POCD group and the POCD + EA group. The POCD animal model was established using sevoflurane anesthesia and tibial fracture.
Bone Health and Physical Activity - The Complex Mechanism.
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Department of Biomechanics, Poznan University of Physical Education, Poznań, Poland.
This review summarizes the mechanism and role of physical activity in maintaining the proper functioning of the musculoskeletal system. Bone adaptation to the mechanical environment occurs in skeletal regions subjected to the greatest stresses resulting from the nature of exercise, however, there is a varied response of bone tissue to mechanical loads depending on its material and structural properties (trabecular and cortical). The regulation of bone tissue metabolism during physical exercise is influenced by factors associated with mechanical stress (gravitational forces, impact loading, and muscular contractions) as well as by systemic mechanisms (hormones, myokines, cytokines).
View Article and Find Full Text PDFAssessment of the correlation between the Vittel criteria and the ISS score: A novel approach to pre-hospital severe trauma patient's triage.
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Department of Anesthesiology and Intensive Care, Sahloul University Hospital, Sousse, Tunisia.
Unlabelled: Introduction-Aim: Validated triage tools such as the Vittel criteria are essential to improve the care of trauma patients. The aim of this study was to evaluate the correlation between the Vittel triage criteria and the Injury Severity Score (ISS) to improve the accuracy of pre-hospital triage.
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Chronic fracture-related infection is a complex, costly clinical problem with a wide spectrum of clinical presentations. The goals of treatment are infection control with a healed fracture covered by well-vascularized soft tissue and improvement of patient pain and function. Management is both medical, with culture-targeted antimicrobial agents, and surgical, requiring meticulous irrigation and débridement.
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Article Synopsis
- Traumatic out-of-hospital cardiac arrest (TOHCA) is a significant public health issue in Thailand, heavily influenced by high accident rates and inconsistent prehospital care.
- A study analyzed data from the Emergency Medicine System over 11 years, finding that of 35,724 TOHCA patients, about 18.5% survived to hospital admission, with key factors influencing survival including stopping bleeding, intubation, and defibrillation.
- The research suggests that improving prehospital management—such as fluid administration and timely intervention—can enhance survival rates for TOHCA victims.
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