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All-cause hospital admissions and incidence of asthma in children in Kazakhstan: a population-based retrospective cohort study.
Sci Rep
March 2025
Department of Medicine, Nazarbayev University School of Medicine, Kerey and Zhanibek Khans Street 5/1, 010000, Astana, Kazakhstan.
This study describes the incidence of asthma and all-cause hospital admissions among children in Kazakhstan diagnosed between 2014 and 2021. In this retrospective cohort study, we included children aged 0-17 years diagnosed with asthma (ICD-10 codes J45.x) and registered in the Unified National Electronic Health System (UNEHS) during 2014-2021.
View Article and Find Full Text PDFAnaphylactic shock is a severe, potentially life-threatening systemic allergic reaction. It can involve multiple organ systems and is triggered by medication, food, or insect stings. Epidemiological data vary due to differing definitions, but studies estimate that 0,26% of hospital admissions are due to anaphylaxis, with 1-3 deaths per million annually.
View Article and Find Full Text PDFObservational birth cohorts for causal and predictive inference: The example of childhood asthma and allergic diseases.
J Allergy Clin Immunol
March 2025
Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, United States. Electronic address:
Prospective birth cohort studies have identified important factors associated with the development and occurrence of early life conditions and facilitated exploration of causal mechanisms. This paper discusses strengths, importance, and biases of birth cohort data for causal inference and predictive modeling, using childhood asthma and allergic disease research as an illustrative example. State-of-the-art study design and statistical methodologies are considered and recommended to mitigate bias and infer causality, as well as using cohort assembly for increased power, sample size, and generalizability.
View Article and Find Full Text PDFRisk, determinants, and persistence of long-COVID in a population-based cohort study in Catalonia.
BMC Med
March 2025
ISGlobal, Barcelona, Spain.
Background: Long-COVID has mostly been investigated in clinical settings. We aimed to assess the risk, subtypes, persistence, and determinants of long-COVID in a prospective population-based study of adults with a history of SARS-CoV-2 infection in Catalonia.
Methods: We examined 2764 infected individuals from a population-based cohort (COVICAT) established before the pandemic and followed up three times across the pandemic (2020, 2021, 2023).
Adverse childhood experiences (ACEs) and repeated wheezing from 6 to 30 months of age: exploring the role of race and ethnicity.
Stress
December 2025
Department of Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Identifying children at risk for respiratory disorders involves understanding early risk factors. This study prospectively examines how specific types of early adversity influence childhood wheeze and how these vary by race and ethnicity. Analyses included N = 746 mother-infant dyads from an urban pregnancy cohort.
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