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Epigenetic Impacts of Non-Coding Mutations Deciphered Through Pre-Trained DNA Language Model at Single-Cell Resolution.
Adv Sci (Weinh)
January 2025
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200230, China.
DNA methylation plays a critical role in gene regulation, affecting cellular differentiation and disease progression, particularly in non-coding regions. However, predicting the epigenetic consequences of non-coding mutations at single-cell resolution remains a challenge. Existing tools have limited prediction capacity and struggle to capture dynamic, cell-type-specific regulatory changes that are crucial for understanding disease mechanisms.
View Article and Find Full Text PDFAn Overview of Early Psychosis Care in New Zealand-A Need for Culturally Adapted Service Models.
Early Interv Psychiatry
February 2025
Health New Zealand-Te Toka Tumai, Auckland, New Zealand.
Background: It has been over 20 years since a review of early psychosis services in New Zealand was completed, and it is unclear if services now meet international best practice. Furthermore, significant disparities in psychosis experiences exist in New Zealand, and it is unclear whether service structure might contribute to such disparities. Given the current restructuring of the health system in New Zealand, now is the optimal time to understand strengths and weaknesses in early psychosis care provision.
View Article and Find Full Text PDFNovel youth mental health services in Australia: What differences are being reported about the clinical needs of those who attend and the outcomes achieved?
Aust N Z J Psychiatry
February 2025
Brain and Mind Centre, The University of Sydney, Camperdown, NSW, Australia.
Globally, youth mental health services are evolving, with Australia's services presented as a leading exemplar. services were designed as enhanced primary care-based entities and were expected to collaborate with local acute, and specialist clinical and psychosocial services. The lack of large-scale health services trials necessitates understanding their impact through systematic monitoring and evaluation.
View Article and Find Full Text PDFAnhedonia relates to reduced striatal reward anticipation in depression but not in schizophrenia or bipolar disorder: A transdiagnostic study.
Cogn Affect Behav Neurosci
January 2025
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences | CCM, Berlin, Germany.
Anhedonia, i.e., the loss of pleasure or lack of reactivity to reward, is a core symptom of major psychiatric conditions.
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