The analysis of blood loss in profound perfusion-free hypothermia has shown that its main cause is that heparin neutralization was performed only after the warming of a patient to 34-35 degrees C. The results of in vitro studies have shown that heparin was effectively neutralized by protamine sulfate at room temperature (20 degrees C). Using protamine sulfate, heparin neutralization was performed at 25-27 degrees C in 90 patients, which reduced blood loss by 10-15% of the circulating blood volume and made it possible to avoid hemotransfusions in the post-operative period.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Aim: Despite obvious progress of surgical technologies in correction of proximal aortic pathology, improvement of methods of protection of the brain, one of the main problems of this direction remains the development of postoperative cerebral ischaemia of various degree of manifestation: strokes, transitory ischaemic attacks, or hypoxic encephalopathy. Of special interest is studying the group of patients presenting with aortic dissection, since this pathology may be accompanied by a wide variety of combinations of occlusive and stenotic lesions of the branches of the ascending portion of the aorta and aortic arch (coronary and brachiocephalic basins) by the detached intima.
Material And Methods: Over the period from 1999 to 2011, we operated on a total of 124 patients presenting with DeBakey type I aortic dissection.
The problem of protecting the spinal cord and visceral organs in surgery of distal aortic dissections becomes increasingly important today because of a comparatively high incidence rate of complications. Paraparesis in type 3 dissecting aortic aneurysm (DAA) is noted to occur in ischaemia of the spinal cord lasting more than 56.5+/-12 min and the inclusion into the blood flow of less than two responsible intercostal arteries.
View Article and Find Full Text PDFBlood plasma adrenalin and noradrenaline were measured during correction of acquired mitral defect under conditions of hypothermia without perfusion. Superficial ether anesthesia combined with morphine in a dose of up to 1 mg/kg and droperidol in a dose of up to 0.1 mg/kg did not fully block the sympathoadrenal reaction to cooling.
View Article and Find Full Text PDFTotal triiodothyronine and thyroxine were measured in the blood plasma during different stages of surgery and after it in 26 patients operated on the open heart under conditions of hypothermia without perfusion. Cooling without perfusion did not appreciably affect the levels of thyroid hormones. Only their ratio was evidently changed at cooling below 30 degrees C with the predominant content of thyroxine.
View Article and Find Full Text PDFCarbohydrate metabolism and insulin status have been studied in 89 patients with congenital heart valve defects operated on in conditions of profound perfusion-free hypothermic protection. It has been established that anesthesia, hypothermia, and surgical trauma are accompanied by hyperinsulinemia, which had nothing to do with the introduction of exogenic hormone. Insulin effect is attenuated and insulin resistance develops, which leads to a drop not only in glucose consumption but also in the consumption of glycolysis products.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!