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| http://dx.doi.org/10.1136/bmj.1.1156.353 | DOI Listing |
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Knowledge and Awareness About the Basics of Cardiopulmonary Resuscitation in the Saudi Population.
Cureus
January 2025
Emergency Medicine, Ministry of Health, Riyadh, SAU.
Introduction According to the World Health Organization (WHO), cardiovascular diseases are the leading cause of death globally, accounting for approximately 17 million deaths annually, with sudden cardiac arrest (SCA) as a significant contributor to this alarming statistic. SCA, the abrupt loss of heart function, is a critical medical emergency that requires early recognition and immediate cardiopulmonary resuscitation (CPR) for the effective resuscitation of victims. Various studies have shown a low level of knowledge regarding CPR in the community.
View Article and Find Full Text PDFAdvancements in Public First Responder Programs for Out-of-Hospital Cardiac Arrest: An Updated Literature Review.
Rev Cardiovasc Med
January 2025
Department of Anesthesiology, Intensive Care Medicine, Emergency Medicine, Pain and Palliative Therapy, Asklepios Klinikum Harburg, 21075 Hamburg, Germany.
Out-of-hospital cardiac arrest (OHCA) is a leading cause of death worldwide, with a low survival rate of around 7% globally. Key factors for improving survival include witnessed arrest, bystander cardiopulmonary resuscitation (CPR), and early defibrillation. Despite guidelines advocating for the "chain of survival", bystander CPR and defibrillation rates remain suboptimal.
View Article and Find Full Text PDFCardiovascular Disease and Other Competing Causes of Death in Older Kidney Cancer Patients.
Rev Cardiovasc Med
January 2025
Department of Endocrinology, The Second Affiliated Hospital of Guangzhou Medical University, 510260 Guangzhou, Guangdong, China.
Background: To study the risk of cardiovascular disease (CVD) and other competing causes of death in older kidney cancer patients.
Methods: Data on older patients (aged 65 and above) diagnosed with kidney cancer between 1975 and 2018 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. We delved into the distribution of CVD and other competing causes of death across the entire cohort and in various patient subgroups.
MCU-i4, a mitochondrial Ca uniporter modulator, induces breast cancer BT474 cell death by enhancing glycolysis, ATP production and reactive oxygen species (ROS) burst.
Oncol Res
January 2025
Department of Physiology, China Medical University, Taichung, 404328, Taiwan.
Objectives: Mitochondrial Ca uniporter (MCU) provides a Ca influx pathway from the cytosol into the mitochondrial matrix and a moderate mitochondrial Ca rise stimulates ATP production and cell growth. MCU is highly expressed in various cancer cells including breast cancer cells, thereby increasing the capacity of mitochondrial Ca uptake, ATP production, and cancer cell proliferation. The objective of this study was to examine MCU inhibition as an anti-cancer mechanism.
View Article and Find Full Text PDFSynaptotagmin-1 attenuates myocardial programmed necrosis and ischemia/reperfusion injury through the mitochondrial pathway.
Cell Death Dis
January 2025
Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, and the Department of Physiology, School of Basic Medicine, Shanxi Medical University, Taiyuan, China.
Programmed necrosis/necroptosis greatly contributes to the pathogenesis of cardiac disorders including myocardial infarction, ischemia/reperfusion (I/R) injury and heart failure. However, the fundamental mechanism underlying myocardial necroptosis, especially the mitochondria-dependent death pathway, is poorly understood. Synaptotagmin-1 (Syt1), a Ca sensor, is originally identified in nervous system and mediates synchronous neurotransmitter release.
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