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Clinical Insights into Neurosyphilis Patients with Leptomeningeal Enhancement of Spinal Cord.
Neuropsychiatr Dis Treat
December 2024
National Center for Infectious Disease, Beijing Ditan Hospital Capital Medical University, Beijing, People's Republic of China.
Background And Objectives: This study aims to report the clinical, biological, and imaging features of cross-sectional study of neurosyphilis patients with leptomeningeal enhancement of spinal cord. Here, 51 neurosyphilis patients with leptomeningeal enhancement of spinal cord positivity are described, offering a promise in terms of early diagnosis, thereby enabling timely detection and treatment.
Methods: We retrospectively included all neurosyphilis patients enrolled in this study from December 2019 to January 2024.
Analysis of Neurosyphilis Imaging Methods and Treatment: A Focused Review.
Cureus
November 2024
Medical Education, Geisinger Commonwealth School of Medicine, Scranton, USA.
Article Synopsis
- * Diagnosis relies on cerebrospinal fluid analysis and neuroimaging techniques like MRI and SPECT, and there are recent advances in testing methods and imaging to monitor treatment effectiveness.
- * The main treatment is Penicillin G, while ceftriaxone is an alternative for those allergic to penicillin; both aim to improve patient outcomes by enhancing understanding of neurosyphilis pathophysiology and refining diagnostic and treatment methods.
[Diagnostic, Therapeutic and Monitoring Approach in Suspected Neurosyphilis: Proposal for a Clinical Guideline].
Acta Med Port
December 2024
Serviço de Doenças Infeciosas. Unidade Local de Saúde de São João. Porto; Departamento de Medicina. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.
This clinical guideline was designed to serve as a hospital guide in the diagnostic, therapeutic, and monitoring approach to neurosyphilis, considering whether there is positivity or not for the human immunodeficiency virus. Syphilis is a sexually transmitted notifiable disease, known as the great imitator. In around 30% of cases of untreated disease, there is a persistent central nervous system infection.
View Article and Find Full Text PDFCharcot's Arthropathy of the Wrist: A Case Report.
J Orthop Case Rep
November 2024
Department of Orthopaedics, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Article Synopsis
- Charcot arthropathy is a joint condition characterized by significant bone degeneration, often resulting from microtrauma that affects articular nerves, with syringomyelia being a common cause in the upper extremities.
- A case study of a 64-year-old man showed painless swelling and deformity in his right wrist, with imaging revealing degenerative changes and conditions like Type II Chiari malformation and myelopathy.
- Diagnosing wrist Charcot arthropathy is complex and requires excluding common arthritis causes such as rheumatoid arthritis and tuberculosis, and a comprehensive neurological examination is essential to identify other possible underlying issues like diabetes or tabes dorsalis.
Novel and characteristic radiological features of neurosyphilis: a case series.
BMC Neurol
July 2024
Department of Radiology, Japanese Red Cross Society Shizuoka Hospital, 8-2 Otemachi, Aoi Ku, Shizuoka City, Shizuoka Prefecture, 420- 0853, Japan.
Background: Treponema pallidum can invade the central nervous system (CNS) early in its infection, causing neurosyphilis. Neurosyphilis typically presents with meningovasculitis in the acute or subacute phase, while tabes dorsalis and dementia paralytica are classical conditions in the later stages. However, syphilis is often misdiagnosed as other conditions such as tumors or autoimmune diseases including vasculitis and encephalitis, which is why the condition is known as "The Great Mimicker.
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