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| http://dx.doi.org/10.1136/bmj.1.333.568 | DOI Listing |
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Systematic investigation and validation of peanut genetic transformation via the pollen tube injection method.
Plant Methods
December 2024
Guangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Science, South China Normal University, Guangzhou, Guangdong, P. R. China.
Genetic transformation is a pivotal approach in plant genetic engineering. Peanut (Arachis hypogaea L.) is an important oil and cash crop, but the stable genetic transformation of peanut is still difficult and inefficient.
View Article and Find Full Text PDFKnowledge mining of brain connectivity in massive literature based on transfer learning.
Bioinformatics
November 2024
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China.
Motivation: Neuroscientists have long endeavored to map brain connectivity, yet the intricate nature of brain networks often leads them to concentrate on specific regions, hindering efforts to unveil a comprehensive connectivity map. Recent advancements in imaging and text mining techniques have enabled the accumulation of a vast body of literature containing valuable insights into brain connectivity, facilitating the extraction of whole-brain connectivity relations from this corpus. However, the diverse representations of brain region names and connectivity relations pose a challenge for conventional machine learning methods and dictionary-based approaches in identifying all instances accurately.
View Article and Find Full Text PDFMathematical basis and toolchain for hierarchical optimization of biochemical networks.
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National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India.
Biological signalling systems are complex, and efforts to build mechanistic models must confront a huge parameter space, indirect and sparse data, and frequently encounter multiscale and multiphysics phenomena. We present HOSS, a framework for Hierarchical Optimization of Systems Simulations, to address such problems. HOSS operates by breaking down extensive systems models into individual pathway blocks organized in a nested hierarchy.
View Article and Find Full Text PDFOptimization of sowing dates for enhanced rice yield: insights from field experiments in the middle and lower reaches of the Yangtze River, China.
BMC Plant Biol
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Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei, Anhui, 230031, China.
An efficacious strategy to adapt to climate change involves optimizing the planting season, a technique that has been extensively utilized to enhance the use of solar radiation and temperature resources in rice cultivation. Field experiments were executed in the middle and lower reaches of the Yangtze River, China, employing three distinct rice cultivars and seven disparate sowing periods spanning 2019 to 2021. The objective of assessing the impact of sowing date on apparent radiation use efficiency (RUE), accumulated temperature use efficiencies (TUE), and overall rice yield.
View Article and Find Full Text PDFEnhanced tumor control and survival in preclinical models with adoptive cell therapy preceded by low-dose radiotherapy.
Front Oncol
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Department of Radiation Oncology-Research, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Introduction: Effective infiltration of chimeric antigen receptor T (CAR-T) cells into solid tumors is critical for achieving a robust antitumor response and improving therapeutic outcomes. While CAR-T cell therapies have succeeded in hematologic malignancies, their efficacy in solid tumors remains limited due to poor tumor penetration and an immunosuppressive tumor microenvironment. This study aimed to evaluate the potential of low-dose radiotherapy (LDRT) administered before T-cell therapy to enhance the antitumor effect by promoting CAR-T cell infiltration.
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