Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12098-010-0145-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synthesis and Evaluation of Halogenated Pralidoximes in Reactivation of Organophosphate-Inhibited Cholinesterases.
ACS Med Chem Lett
December 2024
University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
Organophosphorus compounds are highly toxic irreversible inhibitors of cholinesterases, causing the disruption of cholinergic functions. Treatment of poisoning includes causal antidotes (oximes) used as reactivators of inhibited cholinesterases, such as pralidoxime. In this work, new halogenated oxime reactivators derived from pralidoxime were developed.
View Article and Find Full Text PDFPrecipitate, preterm labor in acute organophosphate poisoning in pregnancy: a case report.
Ann Med Surg (Lond)
December 2024
Institute Of Medicine, Maharajgunj, Nepal.
Introduction: Acute organophosphorus poisoning (AOPP) during pregnancy is uncommon. When complicated by preterm labor, it presents therapeutic dilemmas due to the lack of established guidelines.
Case Presentation: The authors describe a case of a 19-year-old primigravida at 33 weeks of gestation with AOPP.
Organophosphate pesticide residues in fruits and vegetables in Nigeria: prevalence, environmental impact, and human health implications.
Environ Sci Pollut Res Int
December 2024
African Food Research Network, Gauteng, 0002, Pretoria, South Africa.
Pesticides have become indispensable in modern agriculture, aiding in crop protection, and ensuring food security. However, their extensive use has raised concerns about environmental contamination and human health risks. This manuscript reviews the prevalence of organophosphate pesticide (OPP) use in Nigerian agriculture and explores methods for detecting pesticide residues in fruits and vegetables.
View Article and Find Full Text PDFAcute Paraoxon-Induced Neurotoxicity in a Mouse Survival Model: Oxidative Stress, Dopaminergic System Alterations and Memory Deficits.
Int J Mol Sci
November 2024
Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section and Institute of Biomedicine (IBUB), Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain.
Article Synopsis
- The study investigates the secondary neurotoxicity resulting from severe organophosphorus (OP) poisoning, specifically paraoxon (POX), and its impact on cognitive functions in surviving mice.
- Mice were injected with POX followed by various treatments, resulting in high survival rates but significant neurological changes such as increased lipid peroxidation and alterations in neurotransmitter levels in key brain areas linked to memory.
- Despite no signs of depression or anxiety, the study found long-term memory impairments in the mice, highlighting the model's usefulness for exploring the effects of OP exposure and strategies to combat associated cognitive deficits.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!