NMDA receptors are typically excited by a combination of glutamate and glycine. Here we describe excitatory responses in CNS myelin that are gated by a glycine agonist alone and mediated by NR1/NR3 "NMDA" receptor subunits. Response properties include activation by d-serine, inhibition by the glycine-site antagonist CNQX, and insensitivity to the glutamate-site antagonist d-APV. d-Serine responses were abrogated in NR3A-deficient mice. Our results suggest the presence of functional NR1/NR3 receptors in CNS myelin.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941801 | PMC |
| http://dx.doi.org/10.1523/JNEUROSCI.1593-10.2010 | DOI Listing |
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