AI Article Synopsis
- The study explored how lycopene (LC) and ellagic acid (EA) could protect against testicular cell death (apoptosis) caused by cisplatin (CP) in male rats.
- The control group received a placebo, while different groups were treated with CP alone or in combination with LC or EA.
- Results showed that CP increased apoptotic cell markers and lipid damage but combining LC or EA with CP helped reduce these harmful effects and protect testicular tissue.
Article Abstract
The aim of this study was to investigate the possible protective effects of lycopene (LC) and ellagic acid (EA) on cisplatin (CP)-induced testicular apoptosis in male rats. The control group was treated with placebo; LC, EA and CP groups were given alone LC, EA and CP, respectively; the CP+LC group was treated with a combination of CP and LC; and the CP+EA group was treated with a combination of CP and EA. Although CP significantly increased the number of Bax-positive (apoptotic) cells it had no effect on the number of Bcl-2-positive (antiapoptotic) cells compared with the control group. Administration of CP caused significant increase in lipid peroxidation and nonsignificant decrease in superoxide dismutase (SOD) activity along with some histopathological lesions in testicular tissue. However, combined treatments of LC or EA in addition to CP tended to prevent the CP-induced testicular apoptosis, histopathological lesions and lipid peroxidation.
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| http://dx.doi.org/10.1016/j.phymed.2010.07.008 | DOI Listing |
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