AI Article Synopsis
- The study focuses on the synthesis of thioguanine (TG)-capped gold nanoparticles (Au@TG) and assesses their effectiveness against various bacteria and cancer cells.
- It investigates how TG binds to the gold nanoparticles through different scientific methods such as UV-Vis spectrum and TEM.
- The results indicate that Au@TG exhibits stronger antimicrobial and anticancer properties compared to TG alone, suggesting gold nanoparticles could serve as effective drug delivery systems for cancer treatment.
Article Abstract
Synthesis of thioguanine (TG)-capped Au nanoparticles (Au@TG) and their enhanced in vitro antimicrobial and anticancer efficacy against Micrococcus luteus, Staphylococcus aureus, Pseudomonas aeruginosa, E. coli, Aspergillus fumigatus, Aspergillus niger and Hep2 cancer cell (Human epidermiod cell) have been reported. The nature of binding between 6-TG and the gold nanoparticles via complexation is investigated using ultraviolet-visible spectrum, cyclic voltammetry, transmission electron microscopy, fluorescence and Fourier transform infrared (FT-IR) spectroscopy. The present experimental studies suggests that Au@TG are more potential than TG towards antimicrobial and anticancer activities. Hence, gold nanoparticles have the potential to be used as effective carriers for anticancer drug.
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| http://dx.doi.org/10.1166/jbn.2010.1115 | DOI Listing |
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