Aim: Analysis of hepatitis A (HA) incidence in Tyva Republic in 2008 exploiting traditional epidemiological and molecular methods.
Materials And Methods: Epidemiological analysis of HA cases and contact persons in Erzinsky and Kyzyl regions of Tyva Republic was performed. Class M and G antibodies to HAV were determined in serum samples (n = 28), and HAV RNA--in stool samples (n = 16). Phylogenetic analysis of HAV RNA sequence was performed for VP1/2A region of the HAV genome with length 394 nucleotides.
Results: Cases of HA were registered during 3.5 months. Water supply sources did not have deviations from established standards. According to results of interviews, common food factor, which was able to cause the rise of HA incidence, was not determined. Signs of fecal contamination were revealed on environmental objects in preschool institutions and schools that demonstrate the low level of hygienic behaviour. It was shown that all cases of HA are related with different variants of the virus belonged to genotype IA that points to the absence of common source of infection.
Conclusion: Results of epidemiological and genetic analysis of HAV demonstrate that observed rise in HA incidence in Tyva Republic are connected with phase of seasonal rise of HA incidence, which is characteristic for its perennial dynamics with active realization of contact route of virus transmission.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Two new species are described: Leptochilus (Euleptochilus) barkalovi Fateryga, sp. nov. from Turkmenistan and L.
View Article and Find Full Text PDFThe Immunological and Epidemiological Effectiveness of Pediatric Single-Dose Vaccination against Hepatitis A 9 to 11 Years after Its Implementation in the Tyva Republic, the Russian Federation.
Vaccines (Basel)
August 2024
Laboratory of Viral Hepatitis, Mechnikov Research Institute of Vaccines and Sera, 105064 Moscow, Russia.
Since 2012, universal single-dose HAV vaccination in children aged 3 years and older has been implemented in the Tyva Republic, a region of the Russian Federation. The aim of this prospective non-interventional observational single-center study was to determine the immunological and epidemiological effectiveness of single-dose vaccination against hepatitis A 9 to 11 years after its implementation. The anti-HAV IgG antibodies were determined in two independent cohorts of children who were vaccinated with a single dose of monovalent pediatric inactivated vaccine (HAVRIX 720 EU) in Tyva in 2012 and recruited 9 years (Year 9 Cohort) and 11 years (Year 11 Cohort) after immunization.
View Article and Find Full Text PDFExome Sequencing: the Search for Mutations Associated with Hereditary Breast and Ovarian Cancers in the Tuvan Ethnic Group (A Pilot Study).
Bull Exp Biol Med
April 2024
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Whole exome sequencing of peripheral blood samples from Tuvan females diagnosed with breast and ovarian cancers (BC/OC) was performed to search for new genes involved in BC/OC pathogenesis. Considering the high cost of whole exome sequencing and study material requirements, 9 samples were selected from 61 genomic DNA samples. A mutation in the LGR4 gene (rs34804482) involved in the tumor-mediated Wnt signaling pathway and a mutation in the BRWD1 gene (rs147211854) involved in chromatin remodeling were identified in BC patients.
View Article and Find Full Text PDFIntroduction: Tick-borne infections are of great importance for many regions of Russia, including Eastern Siberia. This unfavorable epidemiological situation can be characterized not only by the circulation of well-known tick-borne infections, but also by the identification of new pathogens, the role of which remains little or generally unexplored. Multicomponent flavi-like viruses can cause infectious diseases in humans and pose a threat to public health.
View Article and Find Full Text PDFInsight into the Natural History of Pathogenic Variant c.919-2A>G in the Gene Involved in Hearing Loss: The Evidence for Its Common Origin in Southern Siberia (Russia).
Genes (Basel)
April 2023
Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Pathogenic variants in the gene leading to nonsyndromic recessive deafness (DFNB4), or Pendred syndrome, are some of the most common causes of hearing loss worldwide. Earlier, we found a high proportion of -related hearing loss with prevailing pathogenic variant c.919-2A>G (69.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!