Background: Nasopharyngeal carcinoma with leptomeningeal involvement is rare and typically has poor prognosis.
Methods And Results: We present a case report of a patient with nasopharyngeal carcinoma who was treated with high-dose intravenous methotrexate and remains asymptomatic and without clinical evidence of disease 6 years later.
Conclusions: Systemic high-dose methotrexate should be evaluated in the treatment of advanced nasopharyngeal carcinoma with central nervous involvement.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715067 | PMC |
| http://dx.doi.org/10.1002/hed.21516 | DOI Listing |
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