Intrathecal synthesis of immunoglobulins in patients with unexplained intermediate uveitis.

Purpose: To assess the value of lumbar punctures in adult patients with unexplained intermediate uveitis (IU).

Methods: Retrospective study of 17 patients with unexplained IU. All the patients underwent physical examination, complete laboratory tests, and cerebrospinal MRI.

Results: Out of the 12 patients who underwent a lumbar puncture, six had oligoclonal bands and/or increased IgG index.

Conclusion: Intrathecal synthesis of immunoglobulins is not rare in patients with unexplained IU. A longer follow-up is mandatory to determine whether intrathecal immunoglobulins synthesis has a predictive value for subsequent progression to multiple sclerosis.