The results of the present study show that Lactobacillus pentosus can produce extracellular bioemulsifiers by utilizing hemicellulosic sugars from grape marc as a source of carbon. The effectiveness of these bioemulsifiers (LPEM) was studied by preparing kerosene/water (K/W) emulsions in the presence and absence of these emulsifiers. Various parameters such as relative emulsion volume (EV), stabilizing capacity (ES), viscosity, and droplet size of K/W emulsions were measured. The EV values for K/W emulsions stabilized by concentrated LPEM were approximately 74.5% after 72 h of emulsion formation, with ES values of 97%. These values were higher than those obtained with dodecyl sodium sulfate as emulsifier (EV=62.3% and ES=87.7%). Additionally, K/W emulsions stabilized by LPEM produced polydisperse emulsions containing droplets of radius between 10 and 40 μm, which were smaller than those obtained for K/W emulsions without LPEM (droplet radius=60-100 μm). Moreover, the viscosity values of the K/W emulsions without and with LPEM were approximately 236 and 495 cP, respectively.
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Sci Rep
November 2021
Sunovion Pharmaceuticals Inc., Marlborough, MA, USA.
WT2725 is a Wilms' tumor gene 1 (WT1)-derived-oligopeptide vaccine designed to induce WT1-specific cytotoxic T-lymphocytes against WT1 tumors in human leukocyte antigen (HLA)-A*0201 and/or HLA-A*0206 patients. Here, we report the results of a phase I study of WT2725. In this phase I, open-label, dose-escalation and expansion two-part study, the WT2725 dosing emulsion was administered as a monotherapy to patients with advanced malignancies known to overexpress WT1, including glioblastoma.
View Article and Find Full Text PDFNutrients
September 2019
BASF SE, Nutrition and Health, Human Nutrition, 68623 Lampertheim, Germany.
Elevated blood concentration of low-density lipoprotein cholesterol (LDLc) is a primary risk factor for developing cardiovascular disease. Lifestyle interventions including an increase in dietary phytosterols as well as medications have proven effective in lowering LDLc. The primary objective of this randomized, placebo controlled, double blind, crossover study was to determine the impact of a new phytosterol emulsion for dietary supplements (1.
View Article and Find Full Text PDFArtif Cells Nanomed Biotechnol
May 2017
a Pharmaceutical Research Project Laboratory, Department of Pharmaceutical Sciences , Dr. Hari Singh Gour Vishwavidyalaya , Sagar , Madhya Pradesh , India.
Herein, a nanoemulsion-based organogel (NEOG) system loaded with acyclovir has been developed for the effective treatment of herpes simplex virus infection via topical delivery. Pseudo-ternary phase diagram exhibited increase in non-birefrigent, optically isotropic region of organogel with Smix (K) ratio. The NEOG C showed good storage (G') and loss moduli (G″), and more compact network structures.
View Article and Find Full Text PDFJ Agric Food Chem
September 2010
Departamento de Ingeniería Agroindustrial, Universidad Politécnica de Guanajuato, CP 38483 Mexico.
The results of the present study show that Lactobacillus pentosus can produce extracellular bioemulsifiers by utilizing hemicellulosic sugars from grape marc as a source of carbon. The effectiveness of these bioemulsifiers (LPEM) was studied by preparing kerosene/water (K/W) emulsions in the presence and absence of these emulsifiers. Various parameters such as relative emulsion volume (EV), stabilizing capacity (ES), viscosity, and droplet size of K/W emulsions were measured.
View Article and Find Full Text PDFLangmuir
February 2006
Cavendish Laboratory, University of Cambridge, Madingley Road, Cambridge CB3 0HE, UK.
We study the spontaneous size selection in lyotropic cholesteric (W/O) and thermotropic nematic (O/W) liquid crystal emulsions. The droplet sizes have been characterized by dynamic light scattering, which indicates a narrow monomodal distribution of droplets achieved spontaneously even without emulsion filtration. Anchoring of the director, provided by the chosen surfactant on the interface, may generate a topological defect inside the droplet.
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