AI Article Synopsis
- The study aimed to examine how T-lymphocyte subsets change in patients with severe hepatitis and their impact on clinical outcomes.
- Researchers compared blood samples of 21 severe hepatitis patients to 30 healthy volunteers using flow cytometry to assess T-lymphocyte subsets.
- Results indicated that severe hepatitis patients had lower counts of certain T-lymphocytes compared to healthy controls, and specific changes in these cells could be used to predict survival outcomes in these patients.
Article Abstract
Aim: To study the changing of blood T-lymphocytes subsets in severe hepatitis patients and its effect.
Methods: The T-lymphocytes subsets of 21 patients with severe hepatitis and 30 healthy volunteer were detected by flow cytometry. From the changes of T lymphocytes subsets we compared their related clinical prognosis of each case.
Results: The average CD4(+) CD8(-), CD4(-) CD8(+) lymphocytes counts in severe hepatitis group were lower than the controls groups (P <0.05). And the the CD4(+)/CD8(+) ratios were higher than the control groups (P<0.05). The CD4(+) CD8(-), CD4(-) CD8(+) lymphocytes was lower than severe hepatitis dead group than the surviving group (P<0.05).
Conclusion: The changes of T - lymphocytes subsets especially the elevation of counts CD4(+), CD8(+) lymphocytes may be one important marker to predict the clinical prognosis.
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