Unlabelled: The aim of the study was to investigate the features of immune response in patients with HCV infection on the South of Western Siberia.

Materials: The 130 patients with different genotips of HCV infection were investigated (95 men and 35 women).

Results: On the territory of the South of Western Siberia the 1 and 3 genotips of HCV infection were present especially in young men and women and 1b subtype was dominated. In patients with 1 and 3 genotips of HCV infection was occurred the massive inflammatory response with intensive necrotic proinflammatory cytokins damages of the liver tissue and high cirrotic occurring in young age.

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