Food allergy is a significant health issue in the UK, affecting between 1 and 2% of adults and 5 and 8% of children. The UK Food Standards Agency seeks to ensure the safety of food allergic consumers by providing them with information and guidance on food choices. Since 1995, with the aim of addressing important policy issues and improving the quality of the support and guidance available for food allergic consumers, the Agency (and before that the Ministry of Agriculture, Fisheries and Food), has had a programme of research dedicated to investigating the causes and mechanisms of food allergy and delivering benefits for UK consumers. In this paper, we outline some of the major scientific challenges that the programme has sought to address. We reflect on how the findings have been used as a basis for the development of sound, evidence-based policy and advice for UK consumers, and the current direction of research being supported by the programme.
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http://dx.doi.org/10.1016/j.tox.2010.08.007 | DOI Listing |
Int J Syst Evol Microbiol
January 2025
College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, PR China.
A Gram-stain-negative, aerobic and rod-shaped bacterium, designated as HZG-20, was isolated from a tidal flat in Zhoushan, Zhejiang Province, China. The 16S rRNA sequence similarities between strain HZG-20 and RR4-56, NNCM2, P31 and X9-2-2 were 98.9, 91.
View Article and Find Full Text PDFJAMA Netw Open
January 2025
Program on Regulation, Therapeutics, and Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, Massachusetts.
JAMA Neurol
January 2025
Department of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore.
Importance: Biomarkers would greatly assist decision-making in the diagnosis, prevention, and treatment of chronic pain.
Objective: To undertake analytical validation of a sensorimotor cortical biomarker signature for pain consisting of 2 measures: sensorimotor peak alpha frequency (PAF) and corticomotor excitability (CME).
Design, Setting, And Participants: This cohort study at a single center (Neuroscience Research Australia) recruited participants from November 2020 to October 2022 through notices placed online and at universities across Australia.
J Agric Food Chem
January 2025
Institute of Chemistry, Food Chemistry, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 2, 06120 Halle (Saale), Germany.
Some lactic acid bacteria such as or contain genes encoding 4,6-α-glucanotransferases. These enzymes convert starch and maltodextrins into isomalto/malto-polysaccharides (IMMPs). Many studies focused on the properties of recombinant glucanotransferases, but limited knowledge is available on fermentative synthesis.
View Article and Find Full Text PDFEnzymatic asymmetric synthesis of l-phenylglycine by amino acid dehydrogenases has potential for industrial applications; however, this is hindered by their low catalytic efficiency toward high-concentration substrates. We identified and characterized a novel leucine dehydrogenase (LeuDH) with a high catalytic efficiency for benzoylformic acid via directed metagenomic approaches. Further, we obtained a triple-point mutant LeuDH-EER (D332E/G333E/L334R) with improved stability and catalytic efficiency through the rational design of distal loop 13.
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