AI Article Synopsis
- Felicia muricata leaves, a folk remedy in South Africa, are traditionally used for pain and inflammation, but their scientific validity had not been tested prior to this study.
- The research aimed to evaluate the anti-inflammatory, antinociceptive, and antipyretic effects of the aqueous extract of these leaves through experiments conducted on animals.
- Results showed that the extract significantly reduced pain responses and inflammation while effectively lowering fever, particularly at the highest dosage of 200 mg/kg, supporting its medicinal use in traditional practices.
Article Abstract
Context: Felicia muricata Thunb. (Nees) (Asteraceae) leaves are used in folklore medicine of South Africa as an oral remedy for pain and inflammation. However, the efficacy of the plant part is yet to be validated with scientific experiments.
Objective: The current study is an effort to investigate the anti-inflammatory, antinociceptive, and antipyretic activities of aqueous extract of F. muricata leaves.
Materials And Methods: The phytochemical screening of aqueous extract of Felicia muricata leaves and the efficacy of the extract at the doses of 50, 100, and 200 mg/kg body weight was investigated in experimental animals using several models of inflammation (paw edema induced by carrageenan and egg albumin), nociception (acetic acid-induced writhing, formalin-induced pain and tail immersion), and fever (brewer's yeast-induced hyperthermia).
Results: The extract contained alkaloids, flavonoids, tannins, saponins, and phenolics. The extract dose-dependently reduced (P <0.05) the number of writhes and stretches induced by acetic acid, number of licks induced by formalin, paw volumes induced by carrageenan and egg albumin. The reaction time by the tail of the extract-treated animals to the hot water also increased. The extract also reduced hyperthermia induced by brewer's yeast. The highest dose (200 mg/kg body weight of the extract) produced the best result in all cases.
Discussion And Conclusion: This study revealed that the aqueous extract of Felicia muricata leaves possessed anti-inflammatory, antinociceptive and antipyretic activities. These findings have therefore supported the use of aqueous extract of Felicia muricata leaves in the traditional medicine of South Africa as an oral remedy for pains, inflammation, and fever.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/13880200903373664 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Correlation between Antioxidant Capacity and Phenolic Compounds of Korean Red Pine (Pinus densiflora Sieb. et Zucc.) Bark Fractions under In Vitro Gastrointestinal Digestive Conditions.
Plant Foods Hum Nutr
January 2025
Department of Food Science and Biotechnology, Kyung Hee University, Yongin, 17104, Republic of Korea.
This study investigated the correlations between phenolic compounds and antioxidant capacities of Korean red pine (Pinus densiflora Sieb. et Zucc.) bark (RPB) fractions after in vitro gastrointestinal digestion.
View Article and Find Full Text PDFAqueous and ethanolic extracts of Moringa oleifera leaves induce selective cytotoxicity in Raji and Jurkat cell lines by activating the P21 pathway independent of P53.
Mol Biol Rep
January 2025
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Background: The traditional use of Moringa oleifera (MO), an essential food source in Africa and Asia, to cure various diseases dates back thousands of years. This study examines the aqueous and ethanolic leaf extracts of MO's in vitro anti-leukemia capabilities.
Methods: After preparing aqueous and ethanolic MO leaf extracts, cells were treated with various concentrations for 48 h.
Single-wall carbon nanotube separations aqueous two-phase extraction: new prospects enabled by high-throughput methods.
Chem Commun (Camb)
January 2025
Materials Science and Engineering Division, National Institute of Standards and Technology, Gaithersburg, MD 21045, USA.
Aqueous two-phase extraction (ATPE) is an effective and scalable liquid-phase processing method for purifying single species of single-wall carbon nanotubes (SWCNTs) from multiple species mixtures. Recent metrological developments have led to advances in the speed of identifying solution parameters leading to more efficient ATPE separations with greater fidelities. In this feature article, we review these developments and discuss their vast potential to further advance SWCNT separations science towards the optimization of production scale processes and the full realization of SWCNT-enabled technologies.
View Article and Find Full Text PDFPotential Antioxidant Effects of Common Omani Ethnobotanical Plants.
Prev Nutr Food Sci
December 2024
Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat 123, Oman.
Phytonutrients (e.g., phenolic compounds and flavonoids) are secondary plant metabolites that play an important role in the defense against pathogens and protection from oxidative injury because of their potential ability to neutralize reactive oxygen species.
View Article and Find Full Text PDFSelective extraction of lithium over alkali and alkaline earth ions by synergistic solvent extraction.
Green Chem
December 2024
KU Leuven, Department of Chemistry Celestijnenlaan 200F P.O. box 2404 B-3001 Leuven Belgium
Direct lithium extraction (DLE) from natural surface and geothermal brines is very challenging due to the low ratio of lithium to other metals, and the lack of suitable materials that bind lithium with sufficiently high selectivity. In this paper, a synergistic solvent extraction system is described that comprises a liquid ion exchanger (saponified bis(2-ethylhexyl)dithiophosphoric acid) and a lithium-selective ligand (2,9-dibutyl-1,10-phenanthroline) in an aliphatic diluent. The extraction mechanism was investigated and was confirmed to involve the binding of lithium to the selective ligand, while the liquid ion exchanger facilitates the transfer of metal ions from the aqueous to the organic phase.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!