Primary carcinosarcoma is a very rare neoplasm comprising two intermingling malignant components-epithelial and mesenchymal. The authors report a new case of primary cutaneous carcinosarcoma involving the helix of the ear. Immunohistochemical analysis revealed epithelial components of both basal cell and squamous cell carcinomas with a partially ossified sarcomatous-like component.Cutaneous carcinosarcoma (CS) is a neoplasm with dual epithelial and mesenchymal malignant components. It is most commonly seen in elderly males on sun-exposed areas of the body.(1-2) The histogenesis of CS is currently under debate. Immunohistochemistry plays an integral part in the diagnosis of this rare biphasic neoplasm. After a review of the literature, the authors were able to find only four other reported cases of CS involving the ear.(1,3) They present the fifth case of primary cutaneous CS, which involved the helix of the ear.
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BMJ Support Palliat Care
December 2024
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Objective: To determine if anaemia and blood transfusions in the perioperative, chemotherapy and radiation treatment periods are associated with overall survival (OS) and recurrence-free survival (RFS) in high-grade endometrial cancer.
Methods: This retrospective cohort study examined patients at a single centre treated for high-grade endometrial cancer (2010-2023). This included International Federation of Gynecology and Obstetrics (FIGO) grade 3 endometrioid, serous, carcinosarcoma, mixed, clear cell, mucinous, dedifferentiated and undifferentiated histology.
Medicine (Baltimore)
December 2024
Departments of Medical Oncology, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang, China.
Rationale: Primary sarcomatoid carcinoma of the trachea (PSCT) is a rare malignant tumor of the lower respiratory tract. Pathological types of tracheal sarcomatoid carcinoma (TSC)s include pleomorphic carcinomas, giant cell carcinomas, spindle cell carcinomas, pulmonoblastomas, and carcinosarcomas. At present, there are limited reports on PSCT, and pathologists lack sufficient knowledge about it.
View Article and Find Full Text PDFBiomedicines
November 2024
Division of Abdominal Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu 610065, China.
Background: Head and neck carcinosarcoma (HNCS) is a rare and highly aggressive malignancy with limited research, resulting in an incomplete understanding of disease progression and a lack of reliable prognostic tools. This study aimed to retrospectively analyze the clinical characteristics and outcomes of HNCS patients using data from the Surveillance, Epidemiology, and End Results (SEER) database and to develop a nomogram to predict overall survival (OS) and cancer-specific survival (CSS).
Methods: Patients diagnosed with HNCS from 1975 to 2020 were identified in the SEER database.
Cancer Res
November 2024
University of Michigan-Ann Arbor, Ann Arbor, MI, United States.
Uterine serous carcinoma (USC) and uterine carcinosarcoma (UCS) tumors are uniquely aggressive, suggesting that the primary tumor is intrinsically equipped to disseminate and metastasize. Previous work identified mutational hotspots within PPP2R1A, which encodes the Aα scaffolding subunit of protein phosphatase 2A (PP2A), a heterotrimeric serine/threonine phosphatase. Two recurrent heterozygous PPP2R1A mutations, P179R and S256F, occur exclusively within high-grade subtypes of uterine cancer and can drive tumorigenesis and metastasis.
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