Leucine-rich repeat kinase-2 (LRRK2) mutations are a common cause of Parkinson's disease. Here we identify inhibitors of LRRK2 kinase that are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration. These results establish that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for the treatment of Parkinson's disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935926 | PMC |
| http://dx.doi.org/10.1038/nm.2199 | DOI Listing |
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