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Tongue squamous cell carcinoma treated by 5-aminolevulinic acid administrated through Microdrop method.
Photodiagnosis Photodyn Ther
October 2024
Department of Immunotherapy, the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China. Electronic address:
Article Synopsis
- Postoperative recurrence of tongue squamous cell carcinoma (TSCC) is a significant issue for both patients and doctors, as traditional treatments like surgery and radiotherapy can lead to functional impairments and severe side effects.
- A clinical case study evaluated the use of Microdrop aminolevulinic acid (ALA) photodynamic treatment (PDT) in a patient with TSCC, involving a specialized injection method and follow-up assessments at 1 and 4 months.
- Results showed no visible lesions or recurrence after treatment, preserving the patient's tongue function and cosmetic appearance, suggesting that Microdrop ALA-PDT could be a valuable alternative treatment option for select TSCC cases.
Photosensitive AIEgens sensitize bacteria to oxidative damage and modulate the inflammatory responses of macrophages to salvage the photodynamic therapy against MRSA.
Biomaterials
September 2024
Clinical Translational Research Center of Aggregation-Induced Emission, The Second Affiliated Hospital, School of Medicine, School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong, 518172, China. Electronic address:
The urgent need for antimicrobial agents to combat infections caused by multidrug-resistant bacteria facilitates the exploration of alternative strategies such as photosensitizer (PS)-mediated photoinactivation. However, increasing studies have discovered uncorrelated bactericidal activities among PSs possessing similar photodynamic and pathogen-targeted properties. To optimize the photodynamic therapy (PDT) against infections, we investigated three type-I PSs of D-π-A AIEgens TI, TBI, and TTI.
View Article and Find Full Text PDFPhotodynamic therapy may salvage chemotherapy failure in gastric cancer: A case report and a literature review.
Photodiagnosis Photodyn Ther
April 2024
The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030, China; Department of Surgical Oncology, The Second Hospital of Lanzhou University, Lanzhou 730030, China; Gansu Provincial Key Laboratory of Environmental Oncology, Lanzhou 730030, China. Electronic address:
Given the highly heterogeneous characteristics of advanced gastric cancer (GC), most patients must receive neoadjuvant therapy or conversion therapy consisting of chemotherapy to decrease tumor grade and improve the likelihood of complete resection. Drug resistance, however, always leads to an aborted conversion therapy and inevitable death. When meet drug resistance, alternative drug regimens will be applied with immunotherapy or targeted therapy, whose clinical efficacy remains limited when new drug resistance or severer liver and kidney toxicity emerge.
View Article and Find Full Text PDFMultidisciplinary treatment of advanced cervical esophageal adenocarcinoma derived from a gastric inlet patch: A case report.
Oncol Lett
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Department of General and Digestive Surgery, Kanazawa Medical University Hospital, Kahoku, Ishikawa 920-0293, Japan.
A gastric inlet patch (GIP) is an ectopic gastric mucosal lesion usually arising at the cervical esophagus that may rarely cause esophageal adenocarcinoma (EAC). To the best of our knowledge, this is the first case of a GIP-derived EAC that was successfully treated using a multidisciplinary treatment approach. A 64-year-old man was referred to the Department of Gastrointestinal Surgery, Kanazawa University Hospital (Kanazawa, Japan) for surgical treatment of refractory recurrent cervical EAC derived from GIP who had previously been treated with induction chemotherapy, definitive chemoradiotherapy and photodynamic therapy (PDT).
View Article and Find Full Text PDFEditorial: Focal (salvage) treatment for prostate cancer.
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Imperial College, London, United Kingdom.
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