AI Article Synopsis
- B cells mainly acquire antigens from membrane surfaces through active synapse formations between their receptors and antigen surfaces.
- Recent studies have started to explore how antigens reach follicular dendritic cells (FDC) in lymph nodes, which store these antigens for B cells.
- Innovative imaging techniques, like multiphoton intravital microscopy, have revealed new pathways for transporting lymph-borne antigens to B cells, suggesting a shift in understanding lymphocyte and antigen movement in lymph nodes, which may aid in vaccine development.
Article Abstract
Over the past decade, it has become apparent that B cells acquire antigens primarily from membrane surfaces and that uptake is an active process involving a synapse between the B cell receptor, coreceptor, and the antigen surface. However, understanding how antigens are delivered to follicular dendritic cells (FDC), which are the primary depot for B cell antigen within the lymph node follicles, is only recently beginning to be dissected. The application of fluorescent-based imaging techniques such as multiphoton intravital microscopy to visualize trafficking of B cells and antigens into draining lymph nodes has provide insights that would not otherwise be made. At least three novel pathways for transport of lymph-borne antigens to the B cell compartment have been identified. Based on these studies, a new paradigm of how lymphocytes and antigens traffic within the peripheral lymph nodes is evolving. Understanding how the physical properties of the antigen influences its uptake and processing could be relevant in the design of new vaccines.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S0065-2776(10)06001-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!