Objectives: Osteoprotegerin (OPG), a glycoprotein, is a member of the tumor necrotizing factor alpha receptor super-family. By considering the possible role of OPG in cardiovascular disease (CVD), higher incidence of CVD in people with type 2 diabetic nephropathy (T2DN), and anti-atherosclerotic effects of statins, the present study aimed to investigate the effects of lovastatin on serum levels of OPG and soluble receptor activator of nuclear factor-κB ligand (sRANKL) in people with T2DN.
Design And Methods: Thirty patients completed the study course, out of 38 adult male patients with T2DN who were initially enrolled. Lovastatin, 20mg/d, was administered for 90 days. Afterwards, lovastatin was withdrawn for the next 30 days. Serum levels of OPG and sRANKL were measured using commercial ELISA kits at baseline, after 90 days of intervention, and after 30 days of withdrawal of lovastatin.
Results: Serum level of OPG was significantly increased (10.76 ± 16.44) and decreased (-7.38 ± 11.98) during 90 days of intervention and 30 days of withdrawal periods, respectively, while, sRANKL level was significantly decreased (-1192.08 ± 578.20) and increased (4418.67 ± 2124.66) during the same periods, respectively.
Conclusions: Lovastatin therapy increased serum OPG level and decreased sRANKL level in people with T2DN. The withdrawal of lovastatin decreased serum OPG level, while sRANKL level was extensively increased.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.clinbiochem.2010.08.012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Changes in salivary biomarkers of pain, anxiety, stress, and inflammation related to tooth movement during orthodontic treatment: a systematic review.
Dental Press J Orthod
December 2024
São Leopoldo Mandic School of Dentistry, Department of Molecular Biology (Campinas/SP, Brazil).
Objective: This systematic review aimed to analyze the literature on changes in endogenous salivary biomarkers of pain, anxiety, stress, and inflammation related to tooth movement during orthodontic treatment of children and adolescents.
Material And Methods: An electronic search was performed in nine databases to identify quasi-experimental studies, without restricting publication language and year. Two reviewers extracted the data and assessed the individual risk of bias using the JBI tools, and the certainty of evidence using the GRADE tool.
Are the Soluble Receptors sRAGE, sRANKL, and Osteoprotegerin Associated with Anemia in Rheumatoid Arthritis?
Int J Mol Sci
November 2024
Department of Medical Biochemistry, Faculty of Pharmacy, Medical University of Plovdiv, 15A Vasil Aprilov Blvd., 4002 Plovdiv, Bulgaria.
Article Synopsis
- Rheumatoid arthritis (RA) is an autoimmune disease that can cause inflammation and lead to anemia, and this study explores how certain soluble receptors are affected in different RA patient subgroups based on anemia types and iron levels.
- The findings show higher levels of sRAGE and sRANKL in patients with anemia of chronic disease combined with iron deficiency anemia (ACD/IDA), while OPG levels decreased, indicating potential differences in disease effects between anemia types.
- The study concludes that soluble receptors like sRAGE, sRANKL, and OPG could serve as biomarkers in RA patients, helping to identify those at risk for anemia and better understand the condition's progression.
RANKL/RANK contributes to the pathological process of type 2 diabetes mellitus through TRAF3 activation of NIK.
Int Immunopharmacol
December 2024
Department of Anesthesiology, Hancheng People's Hospital, Hancheng, Shaanxi 715499, China.
Article Synopsis
- - Diabetic osteoporosis is a problem that can happen to people with diabetes, and a drug called Denosumab helps fight against it by blocking a specific protein (RANKL) in the body.
- - Researchers studied how the RANKL protein affects diabetes, using special lab-made cells and rats to see what happens when sugar levels are high in their blood.
- - They found that using a RANKL blocker (sRANKL-IN-3) helped protect cells that make insulin from getting damaged when there's too much sugar, which is good for people with diabetes.
A transdiagnostic and diagnostic-specific approach on inflammatory biomarkers in eating disorders: A meta-analysis and systematic review.
Psychiatry Res
October 2024
Department of Health Sciences, University of Florence, Florence, Italy. Electronic address:
Eating disorders (EDs) are severe mental illnesses with a multifactorial etiology and a chronic course. Among the biological factors related to pathogenesis and maintenance of EDs, inflammation acquired growing scientific interest. This study aimed to assess the inflammatory profile of EDs, focusing on anorexia nervosa, bulimia nervosa, and including for the first time binge eating disorder.
View Article and Find Full Text PDFInterleukin-18 binding protein regulates mast cell activation and mast cell induced osteoclastogenesis of rheumatoid arthritis.
Clin Exp Rheumatol
July 2024
Division of Rheumatology, Department of Internal Medicine, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Republic of Korea.
Objectives: Mast cell activation induces pathological responses, including increased osteoclastogenesis in rheumatoid arthritis (RA). Interleukin (IL)-18 binding protein (IL-18BP) has anti-inflammatory effects. In this study, we evaluated the effect of IL-18BP on mast cell activation and mast cell induced osteoclastogenesis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!